Metabolic responsiveness of different size adipocytes to fasting and refeeding in the pig

T. D. Etherton, C. E. Allen

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

The effects of fasting (F) and fasting-refeeding (FR) on [U-14C]glucose and [1-14C]palmitate metabolism were examined in pig middle subcutaneous (MSQ) adipocytes fractionated into 20-63, 63-102 and 102-153 μm diameter ranges. Fasting caused a similar decrease in de novo glyceride fatty acid (GFA) and glyceride-glycerol (GG) synthesis from glucose among adipocytes of different size. After refeeding for 2 days, glucose metabolism significantly increased in all fractions, however, the increase did not reach non-fasting levels. There was a disparate increase in glucose metabolism among adipocyte fractions after refeeding. Adipocytes 102-153 μm in diameter had a larger increase in glucose metabolism than smaller adipocytes. Fasting suppressed palmitate esterification rates in 20-63 and 63-102 μm fractions. Esterification by adipocytes 102-153 μm in diameter was not diminished after fasting. An 'overshoot' in esterification by adipocytes 63-102 and 102-153 μm in diameter relative to control adipocytes was observed after refeeding; no 'overshoot' occurred in 20-63 μm adipocytes. These results indicate that adipocytes of different size have markedly different capacities for substrate utilization after F or FR as well as different metabolic adaptations to F or FR.

Original languageEnglish (US)
Pages (from-to)1169-1175
Number of pages7
JournalJournal of Nutrition
Volume110
Issue number6
StatePublished - Dec 1 1980

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

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