Metabolie syndrome and altered gut microbiota in mice lacking toll-like receptor 5

Matam Vijay Kumar, Jesse D. Aitken, Frederic A. Carvalho, Tyler C. Cullender, Simon Mwangi, Shanthi Srinivasan, Shanthi V. Sitaraman, Rob Knight, Ruth E. Ley, Andrew T. Gewirtz

Research output: Contribution to journalArticle

1154 Citations (Scopus)

Abstract

Metabolie syndrome is a group of obesity-related metabolic abnormalities that increase an individual's risk of developing type 2 diabetes and cardiovascular disease. Mere, we show that mice genetically deficient in Toll-like receptor 5 (TLR5), a component of the innate immune system that is expressed in the gut mucosa and that helps defend against infection, exhibit hyperphagia and develop hallmark features of metabolic syndrome, including hyperlipidemia, hypertension, insulin resistance, and increased adiposity. These metabolic changes correlated with changes in the composition of the gut microbiota, and transfer of the gut microbiota from TLR5-deficient mice to wild-type germ-free mice conferred many features of metabolic syndrome to the recipients. Food restriction prevented obesity, but not insulin resistance, in the TLR5-deficient mice. These results support the emerging view that the gut microbiota contributes to metabolic disease and suggest that malfunction of the innate immune system may promote the development of metabolic syndrome.

Original languageEnglish (US)
Pages (from-to)228-231
Number of pages4
JournalScience
Volume328
Issue number5975
DOIs
StatePublished - Apr 9 2010

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Toll-Like Receptor 5
Insulin Resistance
Immune System
Obesity
Hyperphagia
Metabolic Diseases
Adiposity
Hyperlipidemias
Type 2 Diabetes Mellitus
Mucous Membrane
Cardiovascular Diseases
Hypertension
Food
Gastrointestinal Microbiome
Infection

All Science Journal Classification (ASJC) codes

  • General

Cite this

Kumar, M. V., Aitken, J. D., Carvalho, F. A., Cullender, T. C., Mwangi, S., Srinivasan, S., ... Gewirtz, A. T. (2010). Metabolie syndrome and altered gut microbiota in mice lacking toll-like receptor 5. Science, 328(5975), 228-231. https://doi.org/10.1126/science.1179721
Kumar, Matam Vijay ; Aitken, Jesse D. ; Carvalho, Frederic A. ; Cullender, Tyler C. ; Mwangi, Simon ; Srinivasan, Shanthi ; Sitaraman, Shanthi V. ; Knight, Rob ; Ley, Ruth E. ; Gewirtz, Andrew T. / Metabolie syndrome and altered gut microbiota in mice lacking toll-like receptor 5. In: Science. 2010 ; Vol. 328, No. 5975. pp. 228-231.
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Kumar, MV, Aitken, JD, Carvalho, FA, Cullender, TC, Mwangi, S, Srinivasan, S, Sitaraman, SV, Knight, R, Ley, RE & Gewirtz, AT 2010, 'Metabolie syndrome and altered gut microbiota in mice lacking toll-like receptor 5', Science, vol. 328, no. 5975, pp. 228-231. https://doi.org/10.1126/science.1179721

Metabolie syndrome and altered gut microbiota in mice lacking toll-like receptor 5. / Kumar, Matam Vijay; Aitken, Jesse D.; Carvalho, Frederic A.; Cullender, Tyler C.; Mwangi, Simon; Srinivasan, Shanthi; Sitaraman, Shanthi V.; Knight, Rob; Ley, Ruth E.; Gewirtz, Andrew T.

In: Science, Vol. 328, No. 5975, 09.04.2010, p. 228-231.

Research output: Contribution to journalArticle

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Kumar MV, Aitken JD, Carvalho FA, Cullender TC, Mwangi S, Srinivasan S et al. Metabolie syndrome and altered gut microbiota in mice lacking toll-like receptor 5. Science. 2010 Apr 9;328(5975):228-231. https://doi.org/10.1126/science.1179721