Metabolism of O6-propyl and N6-propyl-carbovir in CEM cells

William B. Parker, Sue C. Shaddix, Lucy M. Rose, Phuong T. Pham, Mei Hua, Robert Vince

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The metabolism of O6-propyl-carbovir and N6-propyl-carbovir, two selective inhibitors of HIV replication, has been evaluated in CEM cells. Both compounds were phosphorylated in intact cells to carbovir-5'- triphosphate. The metabolism of these two agents was inhibited by deoxycoformycin and mycophenolic acid, but not erythro-9-(2-hydroxy-3- nonyl)adenine. No evidence of the 5'-triphosphate of either compound was detected in CEM cells.

Original languageEnglish (US)
Pages (from-to)795-804
Number of pages10
JournalNucleosides, Nucleotides and Nucleic Acids
Volume19
Issue number4
DOIs
StatePublished - Jan 1 2000

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Genetics

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