Metabolism-related microRNAs in maternal breast milk are influenced by premature delivery

Molly C. Carney, Andrij Tarasiuk, Susan L. Diangelo, Patricia Silveyra, Abigail Podany, Leann L. Birch, Ian M. Paul, Shannon Kelleher, Steven D. Hicks

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

BackgroundMaternal breast milk (MBM) is enriched in microRNAs, factors that regulate protein translation throughout the human body. MBM from mothers of term and preterm infants differs in nutrient, hormone, and bioactive-factor composition, but the microRNA differences between these groups have not been compared. We hypothesized that gestational age at delivery influences microRNA in MBM, particularly microRNAs involved in immunologic and metabolic regulation.MethodsMBM from mothers of premature infants (pMBM) obtained 3-4 weeks post delivery was compared with MBM from mothers of term infants obtained at birth (tColostrum) and 3-4 weeks post delivery (tMBM). The microRNA profile in lipid and skim fractions of each sample was evaluated with high-throughput sequencing.ResultsThe expression profiles of nine microRNAs in lipid and skim pMBM differed from those in tMBM. Gene targets of these microRNAs were functionally related to elemental metabolism and lipid biosynthesis. The microRNA profile of tColostrum was also distinct from that of pMBM, but it clustered closely with tMBM. Twenty-one microRNAs correlated with gestational age demonstrated limited relationships with method of delivery, but not other maternal-infant factors.ConclusionPremature delivery results in a unique MBM microRNA profile with metabolic targets. This suggests that preterm milk may have adaptive functions for growth in premature infants.

Original languageEnglish (US)
Pages (from-to)226-236
Number of pages11
JournalPediatric Research
Volume82
Issue number2
DOIs
StatePublished - Aug 1 2017

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Metabolism-related microRNAs in maternal breast milk are influenced by premature delivery'. Together they form a unique fingerprint.

  • Cite this

    Carney, M. C., Tarasiuk, A., Diangelo, S. L., Silveyra, P., Podany, A., Birch, L. L., Paul, I. M., Kelleher, S., & Hicks, S. D. (2017). Metabolism-related microRNAs in maternal breast milk are influenced by premature delivery. Pediatric Research, 82(2), 226-236. https://doi.org/10.1038/pr.2017.54