Metallic barcodes for multiplexed bioassays

Sarah E. Brunker, Kristin B. Cederquist, Christine Dolan Keating

Research output: Contribution to journalReview article

44 Citations (Scopus)

Abstract

Both detection and postdiagnosis monitoring are critical for cancer isolation and treatment. Particle-based sensing strategies could help to address these medical needs. This review describes barcoded metallic nanowires as particle scaffolds for multiplexed detection of antigens or nucleic acids. Barcode patterns are compositionally encoded as stripes of gold and silver metal along the nanowire length during fabrication by templated electrodeposition. Particle identification is accomplished using reflectance optical microscopy and can be coupled with fluorescence readout of antigen- or nucleic acid-binding events. Several approaches to multiplexed biodetection based on barcoded nanowires will be described and the potential for these particles in cancer detection will be discussed.

Original languageEnglish (US)
Pages (from-to)695-710
Number of pages16
JournalNanomedicine
Volume2
Issue number5
DOIs
StatePublished - Oct 1 2007

Fingerprint

Nanowires
Bioassay
Biological Assay
bioassay
cancer
Nucleic acids
Antigens
Nucleic Acids
nucleic acid
antigen
gold
Electroplating
social isolation
monitoring
Silver
Electrodeposition
Scaffolds
Gold
Optical microscopy
event

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)

Cite this

Brunker, Sarah E. ; Cederquist, Kristin B. ; Keating, Christine Dolan. / Metallic barcodes for multiplexed bioassays. In: Nanomedicine. 2007 ; Vol. 2, No. 5. pp. 695-710.
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Metallic barcodes for multiplexed bioassays. / Brunker, Sarah E.; Cederquist, Kristin B.; Keating, Christine Dolan.

In: Nanomedicine, Vol. 2, No. 5, 01.10.2007, p. 695-710.

Research output: Contribution to journalReview article

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