Metastatic Renal Cell Carcinoma Risk According to Tumor Size

R. Houston Thompson, Jennifer R. Hill, Yuriy Babayev, Angel Cronin, Matthew G. Kaag, Shilajit Kundu, Melanie Bernstein, Jonathan Coleman, Guido Dalbagni, Karim Touijer, Paul Russo

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Purpose: Recent evidence suggests significantly discordant findings regarding tumor size and the metastasis risk in renal cell carcinoma cases. We present our experience with renal cell carcinoma. We evaluated the association between tumor size and the metastasis risk in a large patient cohort. Materials and Methods: Using our prospectively maintained nephrectomy database we identified 2,691 patients who were treated surgically for a sporadic renal cortical tumor between 1989 and 2008. Associations between tumor size and synchronous metastasis at presentation (M1 renal cell carcinoma) were evaluated with logistic regression models. Metastasis-free survival after surgery was estimated using the Kaplan-Meier method in 2,367 patients who did not present with M1 renal cell carcinoma and were followed postoperatively. Results: Of the 2,691 patients 162 presented with metastatic renal cell carcinoma. Only 1 of 781 patients with a tumor less than 3 cm had M1 renal cell carcinoma at presentation and tumor size was significantly associated with metastasis at presentation (for each 1 cm increase OR 1.25, p <0.001). Of the 2,367 patients who did not present with metastasis metastatic disease developed in 171 during a median 2.8-year followup. In this group only 1 of the 720 patients with renal cell carcinoma less than 3 cm showed de novo metastasis during followup. Metastasis-free survival was significantly associated with tumor size (for each 1 cm increase HR 1.24, p <0.001). Conclusions: In our experience tumor size is significantly associated with synchronous and asynchronous metastases after nephrectomy. Our results suggest that the risk of metastatic disease is negligible in patients with tumors less than 3 cm.

Original languageEnglish (US)
Pages (from-to)41-45
Number of pages5
JournalJournal of Urology
Volume182
Issue number1
DOIs
StatePublished - Jul 1 2009

Fingerprint

Renal Cell Carcinoma
Neoplasm Metastasis
Neoplasms
Nephrectomy
Logistic Models
Survival
Databases
Kidney

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Thompson, R. H., Hill, J. R., Babayev, Y., Cronin, A., Kaag, M. G., Kundu, S., ... Russo, P. (2009). Metastatic Renal Cell Carcinoma Risk According to Tumor Size. Journal of Urology, 182(1), 41-45. https://doi.org/10.1016/j.juro.2009.02.128
Thompson, R. Houston ; Hill, Jennifer R. ; Babayev, Yuriy ; Cronin, Angel ; Kaag, Matthew G. ; Kundu, Shilajit ; Bernstein, Melanie ; Coleman, Jonathan ; Dalbagni, Guido ; Touijer, Karim ; Russo, Paul. / Metastatic Renal Cell Carcinoma Risk According to Tumor Size. In: Journal of Urology. 2009 ; Vol. 182, No. 1. pp. 41-45.
@article{007ecb5715044a4dbada1b58d9f4c206,
title = "Metastatic Renal Cell Carcinoma Risk According to Tumor Size",
abstract = "Purpose: Recent evidence suggests significantly discordant findings regarding tumor size and the metastasis risk in renal cell carcinoma cases. We present our experience with renal cell carcinoma. We evaluated the association between tumor size and the metastasis risk in a large patient cohort. Materials and Methods: Using our prospectively maintained nephrectomy database we identified 2,691 patients who were treated surgically for a sporadic renal cortical tumor between 1989 and 2008. Associations between tumor size and synchronous metastasis at presentation (M1 renal cell carcinoma) were evaluated with logistic regression models. Metastasis-free survival after surgery was estimated using the Kaplan-Meier method in 2,367 patients who did not present with M1 renal cell carcinoma and were followed postoperatively. Results: Of the 2,691 patients 162 presented with metastatic renal cell carcinoma. Only 1 of 781 patients with a tumor less than 3 cm had M1 renal cell carcinoma at presentation and tumor size was significantly associated with metastasis at presentation (for each 1 cm increase OR 1.25, p <0.001). Of the 2,367 patients who did not present with metastasis metastatic disease developed in 171 during a median 2.8-year followup. In this group only 1 of the 720 patients with renal cell carcinoma less than 3 cm showed de novo metastasis during followup. Metastasis-free survival was significantly associated with tumor size (for each 1 cm increase HR 1.24, p <0.001). Conclusions: In our experience tumor size is significantly associated with synchronous and asynchronous metastases after nephrectomy. Our results suggest that the risk of metastatic disease is negligible in patients with tumors less than 3 cm.",
author = "Thompson, {R. Houston} and Hill, {Jennifer R.} and Yuriy Babayev and Angel Cronin and Kaag, {Matthew G.} and Shilajit Kundu and Melanie Bernstein and Jonathan Coleman and Guido Dalbagni and Karim Touijer and Paul Russo",
year = "2009",
month = "7",
day = "1",
doi = "10.1016/j.juro.2009.02.128",
language = "English (US)",
volume = "182",
pages = "41--45",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "1",

}

Thompson, RH, Hill, JR, Babayev, Y, Cronin, A, Kaag, MG, Kundu, S, Bernstein, M, Coleman, J, Dalbagni, G, Touijer, K & Russo, P 2009, 'Metastatic Renal Cell Carcinoma Risk According to Tumor Size', Journal of Urology, vol. 182, no. 1, pp. 41-45. https://doi.org/10.1016/j.juro.2009.02.128

Metastatic Renal Cell Carcinoma Risk According to Tumor Size. / Thompson, R. Houston; Hill, Jennifer R.; Babayev, Yuriy; Cronin, Angel; Kaag, Matthew G.; Kundu, Shilajit; Bernstein, Melanie; Coleman, Jonathan; Dalbagni, Guido; Touijer, Karim; Russo, Paul.

In: Journal of Urology, Vol. 182, No. 1, 01.07.2009, p. 41-45.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Metastatic Renal Cell Carcinoma Risk According to Tumor Size

AU - Thompson, R. Houston

AU - Hill, Jennifer R.

AU - Babayev, Yuriy

AU - Cronin, Angel

AU - Kaag, Matthew G.

AU - Kundu, Shilajit

AU - Bernstein, Melanie

AU - Coleman, Jonathan

AU - Dalbagni, Guido

AU - Touijer, Karim

AU - Russo, Paul

PY - 2009/7/1

Y1 - 2009/7/1

N2 - Purpose: Recent evidence suggests significantly discordant findings regarding tumor size and the metastasis risk in renal cell carcinoma cases. We present our experience with renal cell carcinoma. We evaluated the association between tumor size and the metastasis risk in a large patient cohort. Materials and Methods: Using our prospectively maintained nephrectomy database we identified 2,691 patients who were treated surgically for a sporadic renal cortical tumor between 1989 and 2008. Associations between tumor size and synchronous metastasis at presentation (M1 renal cell carcinoma) were evaluated with logistic regression models. Metastasis-free survival after surgery was estimated using the Kaplan-Meier method in 2,367 patients who did not present with M1 renal cell carcinoma and were followed postoperatively. Results: Of the 2,691 patients 162 presented with metastatic renal cell carcinoma. Only 1 of 781 patients with a tumor less than 3 cm had M1 renal cell carcinoma at presentation and tumor size was significantly associated with metastasis at presentation (for each 1 cm increase OR 1.25, p <0.001). Of the 2,367 patients who did not present with metastasis metastatic disease developed in 171 during a median 2.8-year followup. In this group only 1 of the 720 patients with renal cell carcinoma less than 3 cm showed de novo metastasis during followup. Metastasis-free survival was significantly associated with tumor size (for each 1 cm increase HR 1.24, p <0.001). Conclusions: In our experience tumor size is significantly associated with synchronous and asynchronous metastases after nephrectomy. Our results suggest that the risk of metastatic disease is negligible in patients with tumors less than 3 cm.

AB - Purpose: Recent evidence suggests significantly discordant findings regarding tumor size and the metastasis risk in renal cell carcinoma cases. We present our experience with renal cell carcinoma. We evaluated the association between tumor size and the metastasis risk in a large patient cohort. Materials and Methods: Using our prospectively maintained nephrectomy database we identified 2,691 patients who were treated surgically for a sporadic renal cortical tumor between 1989 and 2008. Associations between tumor size and synchronous metastasis at presentation (M1 renal cell carcinoma) were evaluated with logistic regression models. Metastasis-free survival after surgery was estimated using the Kaplan-Meier method in 2,367 patients who did not present with M1 renal cell carcinoma and were followed postoperatively. Results: Of the 2,691 patients 162 presented with metastatic renal cell carcinoma. Only 1 of 781 patients with a tumor less than 3 cm had M1 renal cell carcinoma at presentation and tumor size was significantly associated with metastasis at presentation (for each 1 cm increase OR 1.25, p <0.001). Of the 2,367 patients who did not present with metastasis metastatic disease developed in 171 during a median 2.8-year followup. In this group only 1 of the 720 patients with renal cell carcinoma less than 3 cm showed de novo metastasis during followup. Metastasis-free survival was significantly associated with tumor size (for each 1 cm increase HR 1.24, p <0.001). Conclusions: In our experience tumor size is significantly associated with synchronous and asynchronous metastases after nephrectomy. Our results suggest that the risk of metastatic disease is negligible in patients with tumors less than 3 cm.

UR - http://www.scopus.com/inward/record.url?scp=67349202279&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67349202279&partnerID=8YFLogxK

U2 - 10.1016/j.juro.2009.02.128

DO - 10.1016/j.juro.2009.02.128

M3 - Article

VL - 182

SP - 41

EP - 45

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 1

ER -

Thompson RH, Hill JR, Babayev Y, Cronin A, Kaag MG, Kundu S et al. Metastatic Renal Cell Carcinoma Risk According to Tumor Size. Journal of Urology. 2009 Jul 1;182(1):41-45. https://doi.org/10.1016/j.juro.2009.02.128