Metering the capillary-driven flow of fluids in paper-based microfluidic devices

Hyeran Noh, Scott T. Phillips

Research output: Contribution to journalArticlepeer-review

138 Scopus citations

Abstract

This article describes an exceedingly simple and low-cost method for metering the capillary-driven flow rate of fluids within three-dimensional (3D) microfluidic, paper-based analytical devices (μ PADs). Initial prototypes of 3D μ PADs control the spatial distribution of fluids within a device, but they provide little control over how quickly (or slowly) fluids move within the device. The methods described in this article provide control over when and how quickly a fluid is distributed into detection zones. These methods are inexpensive (the metering regions are composed of paraffin wax), the devices are easy to fabricate, and they are capable of controlling the flow of fluids to detection zones with precise time delays (e.g., ±6% of the total wicking time). We anticipate that this type of precise control over fluid distribution rates will be useful particularly for point-of-care assays that require multiple steps (where each step requires that the reagents interact for a defined period of time) or for simultaneously displaying the results of multiple different assays on a single device.

Original languageEnglish (US)
Pages (from-to)4181-4187
Number of pages7
JournalAnalytical Chemistry
Volume82
Issue number10
DOIs
StatePublished - May 15 2010

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

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