Metformin-Diet ameliorates coronary heart disease risk factors and facilitates resumption of regular menses in adolescents with polycystic ovary syndrome

C. J. Glueck, Dawit Aregawi, M. Winiarska, M. Agloria, G. Luo, L. Sieve, P. Wang

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Background: In 35 adolescent females (17 ± 2 years) with polycystic ovary syndrome (PCOS), median body mass index (BMI) 30.8 kg/m2, we assessed effeicacy of metformin-diet for 1 year for reduction of weight, insulin, HOMA insulin resistance (IR), cholesterol, triglycerides, and resumption of regular menses. Methods: Calories (26% protein, 44% carbohydrate) were targeted to 1,500-1,800/day if BMI was <25 or to 1,200-1,500/day if BMI was ≥25, along with 2,550 mg metformin. Results: Median weight fell from 82.7 to 79.1 kg (p = 0.009), insulin 16.7 to 13.3 μU/ml (p <0.0001), HOMA IR 3.41 to 2.74 (p = 0.0004), total cholesterol 164 to 151 mg/dl (p = 0.002), and triglyceride 103 to 85 mg/dl (p = 0.006). The percentage of cycles with normal menses rose from a pre-treatment mean of 22% to 74%, p < 0.0001. Conclusions: In adolescents with PCOS, metformin-diet reduces weight, insulin, IR, cholesterol, and triglycerides, and facilitates resumption of regular menses.

Original languageEnglish (US)
Pages (from-to)831-842
Number of pages12
JournalJournal of Pediatric Endocrinology and Metabolism
Volume19
Issue number6
DOIs
StatePublished - Jan 1 2006

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Menstruation
Polycystic Ovary Syndrome
Metformin
Coronary Disease
Insulin Resistance
Triglycerides
Body Mass Index
Cholesterol
Insulin
Diet
Weights and Measures
Weight Loss
Carbohydrates
Proteins
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

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title = "Metformin-Diet ameliorates coronary heart disease risk factors and facilitates resumption of regular menses in adolescents with polycystic ovary syndrome",
abstract = "Background: In 35 adolescent females (17 ± 2 years) with polycystic ovary syndrome (PCOS), median body mass index (BMI) 30.8 kg/m2, we assessed effeicacy of metformin-diet for 1 year for reduction of weight, insulin, HOMA insulin resistance (IR), cholesterol, triglycerides, and resumption of regular menses. Methods: Calories (26{\%} protein, 44{\%} carbohydrate) were targeted to 1,500-1,800/day if BMI was <25 or to 1,200-1,500/day if BMI was ≥25, along with 2,550 mg metformin. Results: Median weight fell from 82.7 to 79.1 kg (p = 0.009), insulin 16.7 to 13.3 μU/ml (p <0.0001), HOMA IR 3.41 to 2.74 (p = 0.0004), total cholesterol 164 to 151 mg/dl (p = 0.002), and triglyceride 103 to 85 mg/dl (p = 0.006). The percentage of cycles with normal menses rose from a pre-treatment mean of 22{\%} to 74{\%}, p < 0.0001. Conclusions: In adolescents with PCOS, metformin-diet reduces weight, insulin, IR, cholesterol, and triglycerides, and facilitates resumption of regular menses.",
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Metformin-Diet ameliorates coronary heart disease risk factors and facilitates resumption of regular menses in adolescents with polycystic ovary syndrome. / Glueck, C. J.; Aregawi, Dawit; Winiarska, M.; Agloria, M.; Luo, G.; Sieve, L.; Wang, P.

In: Journal of Pediatric Endocrinology and Metabolism, Vol. 19, No. 6, 01.01.2006, p. 831-842.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Metformin-Diet ameliorates coronary heart disease risk factors and facilitates resumption of regular menses in adolescents with polycystic ovary syndrome

AU - Glueck, C. J.

AU - Aregawi, Dawit

AU - Winiarska, M.

AU - Agloria, M.

AU - Luo, G.

AU - Sieve, L.

AU - Wang, P.

PY - 2006/1/1

Y1 - 2006/1/1

N2 - Background: In 35 adolescent females (17 ± 2 years) with polycystic ovary syndrome (PCOS), median body mass index (BMI) 30.8 kg/m2, we assessed effeicacy of metformin-diet for 1 year for reduction of weight, insulin, HOMA insulin resistance (IR), cholesterol, triglycerides, and resumption of regular menses. Methods: Calories (26% protein, 44% carbohydrate) were targeted to 1,500-1,800/day if BMI was <25 or to 1,200-1,500/day if BMI was ≥25, along with 2,550 mg metformin. Results: Median weight fell from 82.7 to 79.1 kg (p = 0.009), insulin 16.7 to 13.3 μU/ml (p <0.0001), HOMA IR 3.41 to 2.74 (p = 0.0004), total cholesterol 164 to 151 mg/dl (p = 0.002), and triglyceride 103 to 85 mg/dl (p = 0.006). The percentage of cycles with normal menses rose from a pre-treatment mean of 22% to 74%, p < 0.0001. Conclusions: In adolescents with PCOS, metformin-diet reduces weight, insulin, IR, cholesterol, and triglycerides, and facilitates resumption of regular menses.

AB - Background: In 35 adolescent females (17 ± 2 years) with polycystic ovary syndrome (PCOS), median body mass index (BMI) 30.8 kg/m2, we assessed effeicacy of metformin-diet for 1 year for reduction of weight, insulin, HOMA insulin resistance (IR), cholesterol, triglycerides, and resumption of regular menses. Methods: Calories (26% protein, 44% carbohydrate) were targeted to 1,500-1,800/day if BMI was <25 or to 1,200-1,500/day if BMI was ≥25, along with 2,550 mg metformin. Results: Median weight fell from 82.7 to 79.1 kg (p = 0.009), insulin 16.7 to 13.3 μU/ml (p <0.0001), HOMA IR 3.41 to 2.74 (p = 0.0004), total cholesterol 164 to 151 mg/dl (p = 0.002), and triglyceride 103 to 85 mg/dl (p = 0.006). The percentage of cycles with normal menses rose from a pre-treatment mean of 22% to 74%, p < 0.0001. Conclusions: In adolescents with PCOS, metformin-diet reduces weight, insulin, IR, cholesterol, and triglycerides, and facilitates resumption of regular menses.

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