23 Citations (Scopus)

Abstract

The effect of maternally administered methadone hydrochloride (5 mg/kg) on brain development of off-spring treated during gestation and/or lactation was studied in 21-day-old rats. Animals treated during gestation or lactation were the most severely affected, with reductions in brain weights (12% and 30%,respectively), and DNA values (50% and 34%, respectively) observed.

Original languageEnglish (US)
Pages (from-to)1486-1487
Number of pages2
JournalExperientia
Volume33
Issue number11
DOIs
StatePublished - Nov 1 1977

Fingerprint

Methadone
Lactation
Brain
Pregnancy
Rats
Animals
Weights and Measures
DNA

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "Methadone and brain development",
abstract = "The effect of maternally administered methadone hydrochloride (5 mg/kg) on brain development of off-spring treated during gestation and/or lactation was studied in 21-day-old rats. Animals treated during gestation or lactation were the most severely affected, with reductions in brain weights (12{\%} and 30{\%},respectively), and DNA values (50{\%} and 34{\%}, respectively) observed.",
author = "Zagon, {I. S.} and McLaughlin, {Patricia J.}",
year = "1977",
month = "11",
day = "1",
doi = "10.1007/BF01918824",
language = "English (US)",
volume = "33",
pages = "1486--1487",
journal = "Cellular and Molecular Life Sciences",
issn = "1420-682X",
publisher = "Birkhauser Verlag Basel",
number = "11",

}

Methadone and brain development. / Zagon, I. S.; McLaughlin, Patricia J.

In: Experientia, Vol. 33, No. 11, 01.11.1977, p. 1486-1487.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Methadone and brain development

AU - Zagon, I. S.

AU - McLaughlin, Patricia J.

PY - 1977/11/1

Y1 - 1977/11/1

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