Methylchloroisothiazolinone/methylisothiazolinone (Kathon CG) biocide: Second United States multicenter study of human skin sensitization

James Marks, Jack N. Moss, Jeffrey R. Parno, Robert M. Adams, Donald V. Belsito, Vincent A. DeLeo, Anthony Fransway, Joseph F. Fowler, Howard I. Maibach, C. G. Toby Mathias, James R. Nethercott, Robert L. Rietschel, Elizabeth Sherertz, Frances J. Storrs, James S. Taylor

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: This is the second United States multicenter study of human skin sensitization to methylchloroisothiazolinone/methylisothiazolinone (MCI/MI). From January 1991 through March 1992 patients treated in 11 patch test clinics were patch tested to 100 ppm MCI/MI, formaldehyde 1% aqueous, quaternium-15 2% petrolatum, imidazolidinyl urea 2% petrolatum, and paraben mix 12% petrolatum. Results: Twenty-three of the 1,259 patch test patients (1.8%) had positive patch test reactions to MCI/MI. Thirteen of the 23 (56.5%) were thought to be relevant to the presenting dermatitis. The frequency of positive patch test reactions to the other allergens was quaternium-15, 7.2%; formaldehyde, 7.1%; imidazolidinyl urea, 2.2%; and paraben mix, 1.4%. Conclusion: Skin sensitization to MCI/MI has not changed significantly since the first United States multicenter study in 1988 to 1989. The rate of positive patch test responses to MCI/MI was comparable with that for parabens and imidazolidinyl urea and significantly less than for formaldehyde and quaternium-15.

Original languageEnglish (US)
Pages (from-to)87-89
Number of pages3
JournalAmerican Journal of Contact Dermatitis
Volume4
Issue number2
DOIs
StatePublished - Jan 1 1993

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Patch Tests
Multicenter Studies
Parabens
Petrolatum
Skin
Formaldehyde
Dermatitis
Allergens
5-chloro-2-methyl-4-isothiazolin-3-one
2-methyl-4-isothiazolin-3-one
Kathon 886
quaternium-15
imidazolidinyl urea

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Marks, James ; Moss, Jack N. ; Parno, Jeffrey R. ; Adams, Robert M. ; Belsito, Donald V. ; DeLeo, Vincent A. ; Fransway, Anthony ; Fowler, Joseph F. ; Maibach, Howard I. ; Toby Mathias, C. G. ; Nethercott, James R. ; Rietschel, Robert L. ; Sherertz, Elizabeth ; Storrs, Frances J. ; Taylor, James S. / Methylchloroisothiazolinone/methylisothiazolinone (Kathon CG) biocide : Second United States multicenter study of human skin sensitization. In: American Journal of Contact Dermatitis. 1993 ; Vol. 4, No. 2. pp. 87-89.
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title = "Methylchloroisothiazolinone/methylisothiazolinone (Kathon CG) biocide: Second United States multicenter study of human skin sensitization",
abstract = "Background: This is the second United States multicenter study of human skin sensitization to methylchloroisothiazolinone/methylisothiazolinone (MCI/MI). From January 1991 through March 1992 patients treated in 11 patch test clinics were patch tested to 100 ppm MCI/MI, formaldehyde 1{\%} aqueous, quaternium-15 2{\%} petrolatum, imidazolidinyl urea 2{\%} petrolatum, and paraben mix 12{\%} petrolatum. Results: Twenty-three of the 1,259 patch test patients (1.8{\%}) had positive patch test reactions to MCI/MI. Thirteen of the 23 (56.5{\%}) were thought to be relevant to the presenting dermatitis. The frequency of positive patch test reactions to the other allergens was quaternium-15, 7.2{\%}; formaldehyde, 7.1{\%}; imidazolidinyl urea, 2.2{\%}; and paraben mix, 1.4{\%}. Conclusion: Skin sensitization to MCI/MI has not changed significantly since the first United States multicenter study in 1988 to 1989. The rate of positive patch test responses to MCI/MI was comparable with that for parabens and imidazolidinyl urea and significantly less than for formaldehyde and quaternium-15.",
author = "James Marks and Moss, {Jack N.} and Parno, {Jeffrey R.} and Adams, {Robert M.} and Belsito, {Donald V.} and DeLeo, {Vincent A.} and Anthony Fransway and Fowler, {Joseph F.} and Maibach, {Howard I.} and {Toby Mathias}, {C. G.} and Nethercott, {James R.} and Rietschel, {Robert L.} and Elizabeth Sherertz and Storrs, {Frances J.} and Taylor, {James S.}",
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doi = "10.1097/01634989-199306000-00004",
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Marks, J, Moss, JN, Parno, JR, Adams, RM, Belsito, DV, DeLeo, VA, Fransway, A, Fowler, JF, Maibach, HI, Toby Mathias, CG, Nethercott, JR, Rietschel, RL, Sherertz, E, Storrs, FJ & Taylor, JS 1993, 'Methylchloroisothiazolinone/methylisothiazolinone (Kathon CG) biocide: Second United States multicenter study of human skin sensitization', American Journal of Contact Dermatitis, vol. 4, no. 2, pp. 87-89. https://doi.org/10.1097/01634989-199306000-00004

Methylchloroisothiazolinone/methylisothiazolinone (Kathon CG) biocide : Second United States multicenter study of human skin sensitization. / Marks, James; Moss, Jack N.; Parno, Jeffrey R.; Adams, Robert M.; Belsito, Donald V.; DeLeo, Vincent A.; Fransway, Anthony; Fowler, Joseph F.; Maibach, Howard I.; Toby Mathias, C. G.; Nethercott, James R.; Rietschel, Robert L.; Sherertz, Elizabeth; Storrs, Frances J.; Taylor, James S.

In: American Journal of Contact Dermatitis, Vol. 4, No. 2, 01.01.1993, p. 87-89.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Methylchloroisothiazolinone/methylisothiazolinone (Kathon CG) biocide

T2 - Second United States multicenter study of human skin sensitization

AU - Marks, James

AU - Moss, Jack N.

AU - Parno, Jeffrey R.

AU - Adams, Robert M.

AU - Belsito, Donald V.

AU - DeLeo, Vincent A.

AU - Fransway, Anthony

AU - Fowler, Joseph F.

AU - Maibach, Howard I.

AU - Toby Mathias, C. G.

AU - Nethercott, James R.

AU - Rietschel, Robert L.

AU - Sherertz, Elizabeth

AU - Storrs, Frances J.

AU - Taylor, James S.

PY - 1993/1/1

Y1 - 1993/1/1

N2 - Background: This is the second United States multicenter study of human skin sensitization to methylchloroisothiazolinone/methylisothiazolinone (MCI/MI). From January 1991 through March 1992 patients treated in 11 patch test clinics were patch tested to 100 ppm MCI/MI, formaldehyde 1% aqueous, quaternium-15 2% petrolatum, imidazolidinyl urea 2% petrolatum, and paraben mix 12% petrolatum. Results: Twenty-three of the 1,259 patch test patients (1.8%) had positive patch test reactions to MCI/MI. Thirteen of the 23 (56.5%) were thought to be relevant to the presenting dermatitis. The frequency of positive patch test reactions to the other allergens was quaternium-15, 7.2%; formaldehyde, 7.1%; imidazolidinyl urea, 2.2%; and paraben mix, 1.4%. Conclusion: Skin sensitization to MCI/MI has not changed significantly since the first United States multicenter study in 1988 to 1989. The rate of positive patch test responses to MCI/MI was comparable with that for parabens and imidazolidinyl urea and significantly less than for formaldehyde and quaternium-15.

AB - Background: This is the second United States multicenter study of human skin sensitization to methylchloroisothiazolinone/methylisothiazolinone (MCI/MI). From January 1991 through March 1992 patients treated in 11 patch test clinics were patch tested to 100 ppm MCI/MI, formaldehyde 1% aqueous, quaternium-15 2% petrolatum, imidazolidinyl urea 2% petrolatum, and paraben mix 12% petrolatum. Results: Twenty-three of the 1,259 patch test patients (1.8%) had positive patch test reactions to MCI/MI. Thirteen of the 23 (56.5%) were thought to be relevant to the presenting dermatitis. The frequency of positive patch test reactions to the other allergens was quaternium-15, 7.2%; formaldehyde, 7.1%; imidazolidinyl urea, 2.2%; and paraben mix, 1.4%. Conclusion: Skin sensitization to MCI/MI has not changed significantly since the first United States multicenter study in 1988 to 1989. The rate of positive patch test responses to MCI/MI was comparable with that for parabens and imidazolidinyl urea and significantly less than for formaldehyde and quaternium-15.

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