Methylphenidate enhances prepulse inhibition during processing of task-relevant stimuli in attention-deficit/hyperactivity disorder

Rebecca L. Ashare, Larry W. Hawk, Keri Shiels, Jessica D. Rhodes, William E. Pelham, James G. Waxmonsky

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

ADHD is characterized by inattention, hyperactivity, and disinhibition, including the inability to screen out distracting stimuli. Prepulse inhibition (PPI) of startle indexes a related gating process and is enhanced during attended compared to ignored stimuli. We predicted that PPI during attended stimuli would be enhanced by the stimulant methylphenidate (MPH) and that this effect would be moderated by baseline PPI. Children with ADHD (n=36) completed a baseline day and a randomized, double-blind medication trial (placebo vs. sustained release MPH). Bilateral startle eyeblink EMG was measured during a tone discrimination task. MPH enhanced PPI during attended, but not during ignored stimuli. Extending findings that pretreatment functioning moderates stimulant effects on PPI, this effect tended to be inversely related to baseline PPI. These data fit with the clinical literature on ADHD and the hypothesis that MPH enhances interference control for important environmental stimuli.

Original languageEnglish (US)
Pages (from-to)838-845
Number of pages8
JournalPsychophysiology
Volume47
Issue number5
DOIs
StatePublished - Sep 2010

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Neurology
  • Endocrine and Autonomic Systems
  • Developmental Neuroscience
  • Cognitive Neuroscience
  • Biological Psychiatry

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