MHC class II genes of a marsupial, the red-necked wallaby (Macropus rufogriseus): Identification of new gene families

Susanne Schneider, Vladimir Vincek, Herbert Tichy, Felipe Figueroa, Jan Klein

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

In placental mammals, the class II region of the major histocompatibility complex (Mhc) consists of several gene families which show orthologous relationships in the different species. As these families are not orthologous with the Mhc class II β-chain-encoding gene families of birds, the different mammalian families must have diverged after the separation of birds and mammals ∼250 Mya but before the radiation of placental mammals (60-80 Mya). To obtain further information about the origin of the class II genes in mammals, we studied the β-chain-encoding genes of the wallaby as a representative of marsupials, which split from placental mammals ∼125 Mya. Three β-chain-encoding genes were isolated from a red-necked wallaby (Macropus rufogriseus) cDNA library by using a chimpanzee DRB probe, and their nucleotide sequences were determined. The genes are not orthologous to any of the genes in mammals studied thus far but belong to two new families which we designated Maru-DAB and Maru-DBB. One of the three sequences (DAB2) seems to be derived from a transcribed pseudogene; it lacks the codons specifying the first 51 arnino acid residues of the β2 domain. The fact that the DAB and DBB families have thus far not been found in placental mammals and that none of the DOB, DPB, DQB, or DRB genes seems to be expressed in the one representative marsupial species can be interpreted as suggesting that class II gene families of eutherian and metatherian mammals evolved from different ancestral genes.

Original languageEnglish (US)
Pages (from-to)753-766
Number of pages14
JournalMolecular biology and evolution
Volume8
Issue number6
StatePublished - Nov 1991

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

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