MHC polymorphism and human origins

J. Klein, N. Takahata, F. J. Ayala

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


Analysis of the major histocompatibility complex locus, which governs the recognition of self by the immune system, reveals two profound surprises concerning the evolution of humans: the immune system is much older than the species that it protects, and the ancestral population must have been large, not small. There were many Adams and Eves.

Original languageEnglish (US)
Pages (from-to)78-83+4
JournalScientific American
Issue number6
StatePublished - 1993

All Science Journal Classification (ASJC) codes

  • General


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