Microarray analysis reveals novel features of the muscle aging process in men and women

Dongmei Liu, Maureen A. Sartor, Gustavo A. Nader, Emidio E. Pistilli, Leah Tanton, Charles Lilly, Laurie Gutmann, Heidi B. Iglayreger, Paul S. Visich, Eric P. Hoffman, Paul M. Gordon

Research output: Contribution to journalArticle

32 Scopus citations

Abstract

To develop a global view of muscle transcriptional differences between older men and women and sex-specific aging, we obtained muscle biopsies from the biceps brachii of young and older men and women and profiled the whole-genome gene expression using microarray. A logistic regression-based method in combination with an intensity-based Bayesian moderated t test was used to identify significant sex-and aging-related gene functional groups. Our analysis revealed extensive sex differences in the muscle transcriptome of older individuals and different patterns of transcriptional changes with aging in men and women. In older women, we observed a coordinated transcriptional upregulation of immune activation, extracellular matrix remodeling, and lipids storage; and a downregulation of mitochondrial biogenesis and function and muscle regeneration. The effect of aging results in sexual dimorphic alterations in the skeletal muscle transcriptome, which may modify the risk for developing musculoskeletal and metabolic diseases in men and women.

Original languageEnglish (US)
Pages (from-to)1035-1044
Number of pages10
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume68
Issue number9
DOIs
StatePublished - Sep 2013

All Science Journal Classification (ASJC) codes

  • Aging
  • Geriatrics and Gerontology

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