Microbial determinants of biochemical individuality and their impact on toxicology and pharmacology

Andrew D. Patterson, Peter J. Turnbaugh

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations

Abstract

Humans exhibit remarkable interindividual variations in the concentration of small molecules found throughout the body, due in part to concurrent variations in each person's associated microbial communities. Recent studies have begun to uncover how microbes interface with their host during exposure to drugs, dietary compounds, and environmental toxicants, with broader implications regarding the causes and consequences of biochemical individuality. Progress in this area will likely be an essential component of personalized medicine and might be accelerated through the implementation of experimental designs and theoretical principles honed through decades of work in the fields of toxicology and pharmacology.

Original languageEnglish (US)
Pages (from-to)761-768
Number of pages8
JournalCell Metabolism
Volume20
Issue number5
DOIs
StatePublished - Nov 4 2014

All Science Journal Classification (ASJC) codes

  • Physiology
  • Molecular Biology
  • Cell Biology

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