Microbial oxidation/amidation of benzhydrylsulfanyl acetic acid. Synthesis of (+)-modafinil

Horacio F. Olivo; Antonio Osorio-Lozada; Tonya Peeples

doi:10.1016/j.tetasy.2005.07.028

Microbial oxidation/amidation of benzhydrylsulfanyl acetic acid. Synthesis of (+)-modafinil

Horacio F. Olivo, Antonio Osorio-Lozada, Tonya Peeples

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

A highly enantioselective oxidation of benzhydrylsulfanyl acetic acid to the corresponding (S)-sulfinyl carboxylic acid was achieved employing the fungus Beauveria bassiana in very good yield. This product was amidated using the bacteria Bacillus subtilis to afford (S)-modafinil in good yield.

Original language	English (US)
Pages (from-to)	3507-3511
Number of pages	5
Journal	Tetrahedron Asymmetry
Volume	16
Issue number	21
DOIs	https://doi.org/10.1016/j.tetasy.2005.07.028
State	Published - Oct 31 2005

All Science Journal Classification (ASJC) codes

Catalysis
Physical and Theoretical Chemistry
Organic Chemistry
Inorganic Chemistry

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title = "Microbial oxidation/amidation of benzhydrylsulfanyl acetic acid. Synthesis of (+)-modafinil",

abstract = "A highly enantioselective oxidation of benzhydrylsulfanyl acetic acid to the corresponding (S)-sulfinyl carboxylic acid was achieved employing the fungus Beauveria bassiana in very good yield. This product was amidated using the bacteria Bacillus subtilis to afford (S)-modafinil in good yield.",

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AU - Osorio-Lozada, Antonio

AU - Peeples, Tonya

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