Microbial oxidation/amidation of benzhydrylsulfanyl acetic acid. Synthesis of (+)-modafinil

Horacio F. Olivo, Antonio Osorio-Lozada, Tonya Peeples

Research output: Contribution to journalArticlepeer-review

26 Scopus citations

Abstract

A highly enantioselective oxidation of benzhydrylsulfanyl acetic acid to the corresponding (S)-sulfinyl carboxylic acid was achieved employing the fungus Beauveria bassiana in very good yield. This product was amidated using the bacteria Bacillus subtilis to afford (S)-modafinil in good yield.

Original languageEnglish (US)
Pages (from-to)3507-3511
Number of pages5
JournalTetrahedron Asymmetry
Volume16
Issue number21
DOIs
StatePublished - Oct 31 2005

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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