Microbubble mediated dual-frequency high intensity focused ultrasound thrombolysis: An in vitro study

Dingjie Suo, Zhiyang Jin, Xiaoning Jiang, Paul A. Dayton, Yun Jing

Research output: Contribution to journalArticlepeer-review

41 Scopus citations

Abstract

High intensity focused ultrasound (HIFU) has recently emerged as a promising alternative approach for thrombolysis. However, the high acoustic energy required by HIFU could elicit thermal damage bioeffects, impeding the clinical translation of this technique. This paper investigates the use of dual-frequency focused ultrasound (DFFU) mediated by microbubbles (MBs) to minimize the acoustic power required for thrombolysis in vitro. It was found that MBs, with sufficient concentration, could significantly lower the power threshold for thrombolysis for both DFFU and single-frequency focused ultrasound (SFFU). In addition, SFFU needs about 96%-156% higher energy to achieve the same thrombolysis efficiency as that of DFFU. The thrombolysis efficiency is also found to increase with the duty cycle. The measured cavitation signals reveal that the enhanced inertial cavitation is likely responsible for the improved thrombolysis under DFFU and MBs.

Original languageEnglish (US)
Article number023703
JournalApplied Physics Letters
Volume110
Issue number2
DOIs
StatePublished - Jan 9 2017

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy (miscellaneous)

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