With the growing need for alternative and synthetic fuels, much attention is being devoted to their production using the Fischer-Tropsch (FT) route from non-food resources, e.g., stranded natural gas reserves, coal, and waste. Experimental results for the hydrocracking of FT waxes in a microchannel reactor are presented. The high heat and mass transfer rate advantage of the microreactors is confirmed with higher productivity for the hydrocracking process. A multifold increase in the reactor throughput can be achieved using a microchannel hydrocracker while maintaining a good quality product distribution. This is an abstract of a paper presented at the 2009 AIChE Spring National Meeting and 5th Global Congress on Process Safety (Tampa, FL 4/26-30/2009).