Microcystin-lr decreases hepatic and renal perfusion, and causes circulatory shock, severe hypoglycemia, and terminal hyperkalemia in intravascularly dosed swine

Val Richard Beasley, Randall A. Lovell, Kenneth R. Holmes, Horace E. Walcott, David J. Schaeffer, Walter E. Hoffmann, Wayne W. Carmichael

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Cross-bred, anesthetized female swine were given intravascularly a lethal (72 µg/kg; n = 6) or toxic-sublethal (25 µg/kg; n = 6) dose of microcystin-LR (MCLR), from Microcystis aeruginosa, or the vehicle (n = 4). At the high dose, from 12 to 18 min after administration, central venous pressure and hepatic perfusion were significantly lower, and shortly thereafter, portal venous pressure was significantly higher and aortic mean pressure was significantly lower than controls. By 45 min postdosing, serum bile acids, lactate, potassium, and total bilirubin, as well as blood pO 2 , were significantly higher, while hematocrit, platelet count, and blood bicarbonate, pCO 2 , and base excess were significantly lower than controls. By 90 min, serum arginase, urea nitrogen, inorganic phosphorus, and creatinine were significantly higher, while glucose and blood pH were significantly.

Original languageEnglish (US)
Pages (from-to)281-303
Number of pages23
JournalJournal of Toxicology and Environmental Health - Part A
Volume61
Issue number4
DOIs
StatePublished - Jan 1 2000

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Hyperkalemia
Hypoglycemia
Shock
Swine
Perfusion
Microcystis
Kidney
Portal Pressure
Arginase
Central Venous Pressure
Poisons
Liver
Blood
Bicarbonates
Bile Acids and Salts
Serum
Platelet Count
Hematocrit
Bilirubin
Phosphorus

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Health, Toxicology and Mutagenesis

Cite this

Beasley, Val Richard ; Lovell, Randall A. ; Holmes, Kenneth R. ; Walcott, Horace E. ; Schaeffer, David J. ; Hoffmann, Walter E. ; Carmichael, Wayne W. / Microcystin-lr decreases hepatic and renal perfusion, and causes circulatory shock, severe hypoglycemia, and terminal hyperkalemia in intravascularly dosed swine. In: Journal of Toxicology and Environmental Health - Part A. 2000 ; Vol. 61, No. 4. pp. 281-303.
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Microcystin-lr decreases hepatic and renal perfusion, and causes circulatory shock, severe hypoglycemia, and terminal hyperkalemia in intravascularly dosed swine. / Beasley, Val Richard; Lovell, Randall A.; Holmes, Kenneth R.; Walcott, Horace E.; Schaeffer, David J.; Hoffmann, Walter E.; Carmichael, Wayne W.

In: Journal of Toxicology and Environmental Health - Part A, Vol. 61, No. 4, 01.01.2000, p. 281-303.

Research output: Contribution to journalArticle

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AU - Beasley, Val Richard

AU - Lovell, Randall A.

AU - Holmes, Kenneth R.

AU - Walcott, Horace E.

AU - Schaeffer, David J.

AU - Hoffmann, Walter E.

AU - Carmichael, Wayne W.

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