Microencapsulation of chemotherapeutics into monodisperse and tunable biodegradable polymers via electrified liquid jets: Control of size, shape, and drug release

Pouria Fattahi, Ali Borhan, Mohammad Reza Abidian

Research output: Contribution to journalArticlepeer-review

44 Scopus citations

Abstract

This paper describes microencapsulation of antitumor agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU, Carmustine) into biodegradable polymer poly(lactic-co-glycolic) acid (PLGA) using an electrojetting technique. The resulting BCNU-loaded PLGA microcapsules have significantly higher drug encapsulation efficiency, more tunable drug loading capacity, and (3) narrower size distribution than those generated using other encapsulation methods.

Original languageEnglish (US)
Pages (from-to)4555-4560
Number of pages6
JournalAdvanced Materials
Volume25
Issue number33
DOIs
StatePublished - Sep 6 2013

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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