Microfiltration device for continuous, label-free bacteria separation from whole blood for sepsis treatment

Kiana Aran, Mercedes Morales, Lawrence A. Sasso, Jean Lo, Mingde Zheng, Ian Johnston, Neal Kamdar, Akif Ündar, Jeffrey D. Zahn

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

This work presents the design, fabrication, and testing of a cross-flow filtration microdevice, for the continuous extraction of bacteria from a whole blood sample for the treatment of sepsis and bacteremia. The system consists of a two-compartment microdevice with two aligned sets of PDMS microchannels, separated by a porous polycarbonate (PCTE) membrane with 2 μm pores. When a whole blood sample flows through the channels on one side of the membrane (Reservoir channels), the larger blood cells are sterically excluded from passing through the membrane while the smaller bacteria are removed by traversing the membrane into the filtration channels.

Original languageEnglish (US)
Title of host publication15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Pages497-499
Number of pages3
StatePublished - Dec 1 2011
Event15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 - Seattle, WA, United States
Duration: Oct 2 2011Oct 6 2011

Publication series

Name15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
Volume1

Other

Other15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011
CountryUnited States
CitySeattle, WA
Period10/2/1110/6/11

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering

Cite this

Aran, K., Morales, M., Sasso, L. A., Lo, J., Zheng, M., Johnston, I., Kamdar, N., Ündar, A., & Zahn, J. D. (2011). Microfiltration device for continuous, label-free bacteria separation from whole blood for sepsis treatment. In 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 (pp. 497-499). (15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011; Vol. 1).