Microfluidic platform with hierarchical micro/nanostructures and SELEX nucleic acid aptamer coating for isolation of circulating tumor cells

Vikhram V. Swaminathan, Spandana Gannavaram, Shihui Li, Huan Hu, Junghoon Yeom, Yong Wang, Likun Zhu

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

Microfluidic platforms provide elegant schemes for isolation of rare cells from the blood. Hierarchical 3-dimensional architectures with silicon nanopillar forests draw advantage of unique surface interactions with target cells to aid capture and adhesion. Microchannels with numerically optimized designs of micro post arrays maximize contact frequency with the cells in flow. We describe a scheme to fabricate ordered nanopillar forests on the sidewalls of these micro posts and functionalize them with SELEX nucleic acid aptamers. Our microfluidic platform, designed for 90% contact probability, facilitates technologies for highly selective and specific capture of circulating tumor cells.

Original languageEnglish (US)
Title of host publication2013 13th IEEE International Conference on Nanotechnology, IEEE-NANO 2013
Pages370-373
Number of pages4
DOIs
StatePublished - Dec 1 2013
Event2013 13th IEEE International Conference on Nanotechnology, IEEE-NANO 2013 - Beijing, China
Duration: Aug 5 2013Aug 8 2013

Publication series

NameProceedings of the IEEE Conference on Nanotechnology
ISSN (Print)1944-9399
ISSN (Electronic)1944-9380

Other

Other2013 13th IEEE International Conference on Nanotechnology, IEEE-NANO 2013
CountryChina
CityBeijing
Period8/5/138/8/13

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Electrical and Electronic Engineering
  • Materials Chemistry
  • Condensed Matter Physics

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