Microgeographically diverse Plasmodium vivax populations at the Thai-Myanmar border

Bhavna Gupta, Daniel M. Parker, Qi Fan, B. P.Niranjan Reddy, Guiyun Yan, Jetsumon Sattabongkot, Liwang Cui

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Abstract

Malaria transmission along international borders of the Greater Mekong Subregion is a big challenge for regional malaria elimination. At the Thai-Myanmar border, Plasmodium falciparum cases have dropped dramatically; however, increasing P. vivax prevalence and the emerging reports on hidden malaria burden due to asymptomatic infections demand attention. We conducted cross-sectional surveys to detect asymptomatic malaria infections in a small village located at Thai-Myanmar border and genotyped P. vivax infections in order to understand the level of genetic diversity on such a microgeographic scale. PCR/RFLP and DNA sequencing identified high levels of genetic polymorphisms at both Pvmsp3α and Pvmsp3β loci among P. vivax infections. Combining the PCR/RFLP patterns of Pvmsp3α and Pvmsp3β, a total of 10 genotypes were observed among 17 samples, while concatenated DNA sequences of Pvmsp3α and 3β generated 14 haplotypes with haplotype diversity of 0.97. These markedly diverse parasites on a microgeographic scale suggest the circulation of a considerably large parasite population at the international border.

Original languageEnglish (US)
Pages (from-to)341-346
Number of pages6
JournalInfection, Genetics and Evolution
Volume45
DOIs
StatePublished - Nov 1 2016

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All Science Journal Classification (ASJC) codes

  • Microbiology
  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Gupta, B., Parker, D. M., Fan, Q., Reddy, B. P. N., Yan, G., Sattabongkot, J., & Cui, L. (2016). Microgeographically diverse Plasmodium vivax populations at the Thai-Myanmar border. Infection, Genetics and Evolution, 45, 341-346. https://doi.org/10.1016/j.meegid.2016.09.021