Micromechanics of tumor cell adhesion and migration under dynamic flow conditions

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Abstract

Attachment of tumor cells to endothelial cells is critical for migration of tumor cells out of the vascular system to establish metastases. We have studied human melanoma cell (C8161) adhesion and migration in response to stimulation by soluble collagen IV (CIV) using a modified Boyden chamber. In this modified chamber, shear flow can be introduced over the cell-substrate interface affecting tumor cell chemotactic migration through a microporous filter. Our results suggest that transmigration of C8161 cells under flaw conditions can be influenced by PMNs, mediated by Mac-1/ICAM-1 adhesive interactions and enhanced by altered cytokine production.

Original languageEnglish (US)
Title of host publicationProceedings of the Second IASTED International Conference on Biomechanics
EditorsM.H. Hamza
Pages150-155
Number of pages6
StatePublished - Dec 1 2004
EventProceedings of the Second IASTED International Conference on Biomechanics - Honolulu, HI, United States
Duration: Aug 23 2004Aug 25 2004

Publication series

NameProceedings of the Second IASTED International Conference on Biomechanics

Other

OtherProceedings of the Second IASTED International Conference on Biomechanics
CountryUnited States
CityHonolulu, HI
Period8/23/048/25/04

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All Science Journal Classification (ASJC) codes

  • Engineering(all)

Cite this

Dong, C., Slattery, M., & Liang, S. (2004). Micromechanics of tumor cell adhesion and migration under dynamic flow conditions. In M. H. Hamza (Ed.), Proceedings of the Second IASTED International Conference on Biomechanics (pp. 150-155). [463-053] (Proceedings of the Second IASTED International Conference on Biomechanics).