Micromotors Powered by Enzyme Catalysis

Krishna K. Dey, Xi Zhao, Benjamin M. Tansi, Wilfredo J. Méndez-Ortiz, Ubaldo M. Córdova-Figueroa, Ramin Golestanian, Ayusman Sen

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Active biocompatible systems are of great current interest for their possible applications in drug or antidote delivery at specific locations. Herein, we report the synthesis and study of self-propelled microparticles powered by enzymatic reactions and their directed movement in substrate concentration gradient. Polystyrene microparticles were functionalized with the enzymes urease and catalase using a biotin-streptavidin linkage procedure. The motion of the enzyme-coated particles was studied in the presence of the respective substrates, using optical microscopy and dynamic light scattering analysis. The diffusion of the particles was found to increase in a substrate concentration dependent manner. The directed chemotactic movement of these enzyme-powered motors up the substrate gradient was studied using three-inlet microfluidic channel architecture.

Original languageEnglish (US)
Pages (from-to)8311-8315
Number of pages5
JournalNano letters
Volume15
Issue number12
DOIs
StatePublished - Dec 9 2015

Fingerprint

micromotors
Micromotors
Catalysis
catalysis
enzymes
Enzymes
microparticles
Substrates
antidotes
catalase
Antidotes
gradients
biotin
Streptavidin
Urease
Polystyrenes
Dynamic light scattering
Biotin
Microfluidics
linkages

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

Cite this

Dey, K. K., Zhao, X., Tansi, B. M., Méndez-Ortiz, W. J., Córdova-Figueroa, U. M., Golestanian, R., & Sen, A. (2015). Micromotors Powered by Enzyme Catalysis. Nano letters, 15(12), 8311-8315. https://doi.org/10.1021/acs.nanolett.5b03935
Dey, Krishna K. ; Zhao, Xi ; Tansi, Benjamin M. ; Méndez-Ortiz, Wilfredo J. ; Córdova-Figueroa, Ubaldo M. ; Golestanian, Ramin ; Sen, Ayusman. / Micromotors Powered by Enzyme Catalysis. In: Nano letters. 2015 ; Vol. 15, No. 12. pp. 8311-8315.
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Dey, KK, Zhao, X, Tansi, BM, Méndez-Ortiz, WJ, Córdova-Figueroa, UM, Golestanian, R & Sen, A 2015, 'Micromotors Powered by Enzyme Catalysis', Nano letters, vol. 15, no. 12, pp. 8311-8315. https://doi.org/10.1021/acs.nanolett.5b03935

Micromotors Powered by Enzyme Catalysis. / Dey, Krishna K.; Zhao, Xi; Tansi, Benjamin M.; Méndez-Ortiz, Wilfredo J.; Córdova-Figueroa, Ubaldo M.; Golestanian, Ramin; Sen, Ayusman.

In: Nano letters, Vol. 15, No. 12, 09.12.2015, p. 8311-8315.

Research output: Contribution to journalArticle

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Dey KK, Zhao X, Tansi BM, Méndez-Ortiz WJ, Córdova-Figueroa UM, Golestanian R et al. Micromotors Powered by Enzyme Catalysis. Nano letters. 2015 Dec 9;15(12):8311-8315. https://doi.org/10.1021/acs.nanolett.5b03935