TY - JOUR
T1 - Micro/nanodevices for assessment and treatment in stomatology and ophthalmology
AU - Sheng, An’an
AU - Lin, Long
AU - Zhu, Jia
AU - Zhuang, Jian
AU - Li, Jian
AU - Chang, Lingqian
AU - Cheng, Huanyu
N1 - Funding Information:
L.C. acknowledges support from the NSFC (No. 32071407 and No. 62003023) and Beijing Advanced Innovation Center for Biomedical Engineering. H.C. acknowledges support from the Doctoral New Investigator grant from the American Chemical Society Petroleum Research Fund (59021-DNI7), the National Science Foundation (ECCS-1933072), and Pennsylvania State University. J.Z. acknowledges support from the Leighton Riess Graduate Fellowship in Engineering from Pennsylvania State University.
Publisher Copyright:
© 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Micro/nanodevices have been widely applied for the real-time monitoring of intracellular activities and the delivery of exogenous substances in the past few years. This review focuses on miniaturized micro/nanodevices for assessment and treatment in stomatology and ophthalmology. We first summarize the recent progress in this field by examining the available materials and fabrication techniques, device design principles, mechanisms, and biosafety aspects of micro/nanodevices. Following a discussion of biochemical sensing technology from the cellular level to the tissue level for disease assessment, we then summarize the use of microneedles and other micro/nanodevices in the treatment of oral and ocular diseases and conditions, including oral cancer, eye wrinkles, keratitis, and infections. Along with the identified key challenges, this review concludes with future directions as a small fraction of vast opportunities, calling for joint efforts between clinicians and engineers with diverse backgrounds to help facilitate the rapid development of this burgeoning field in stomatology and ophthalmology.
AB - Micro/nanodevices have been widely applied for the real-time monitoring of intracellular activities and the delivery of exogenous substances in the past few years. This review focuses on miniaturized micro/nanodevices for assessment and treatment in stomatology and ophthalmology. We first summarize the recent progress in this field by examining the available materials and fabrication techniques, device design principles, mechanisms, and biosafety aspects of micro/nanodevices. Following a discussion of biochemical sensing technology from the cellular level to the tissue level for disease assessment, we then summarize the use of microneedles and other micro/nanodevices in the treatment of oral and ocular diseases and conditions, including oral cancer, eye wrinkles, keratitis, and infections. Along with the identified key challenges, this review concludes with future directions as a small fraction of vast opportunities, calling for joint efforts between clinicians and engineers with diverse backgrounds to help facilitate the rapid development of this burgeoning field in stomatology and ophthalmology.
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U2 - 10.1038/s41378-021-00238-1
DO - 10.1038/s41378-021-00238-1
M3 - Review article
C2 - 33532080
AN - SCOPUS:85100100964
SN - 2055-7434
VL - 7
JO - Microsystems and Nanoengineering
JF - Microsystems and Nanoengineering
IS - 1
M1 - 11
ER -
