MicroRNA-340 as a modulator of RAS-RAF-MAPK signaling in melanoma

Ashley M. Poenitzsch Strong, Vijayasaradhi Setaluri, Vladimir Spiegelman

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

microRNA (miRNA)-dependent regulation of gene expression is increasingly linked to development and progression of melanoma. In this study we evaluated the functions of miR-340 in human melanoma cells. Here, we show that miR-340 inhibits the tumorigenic phenotype of melanoma cells. We also found that miR-340 regulates RAS-RAF-Mitogen Activated Protein Kinase (MAPK) signaling by modulating the expression of multiple components of this pathway. Given the importance of MAPK signaling in melanoma, these results provide further insight into the pathogenesis of melanoma.

Original languageEnglish (US)
Pages (from-to)118-124
Number of pages7
JournalArchives of Biochemistry and Biophysics
Volume563
DOIs
StatePublished - Dec 15 2014

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology

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