TY - JOUR
T1 - MicroRNA expression altered by diet
T2 - Can food be medicinal?
AU - Palmer, Joshua D.
AU - Soule, Benjamin P.
AU - Simone, Brittany A.
AU - Zaorsky, Nicholas G.
AU - Jin, Lianjin
AU - Simone, Nicole L.
N1 - Funding Information:
Research support was in part through the Kimmel Cancer Center's NCI Cancer Center Support Grant P30 CA56036 .
PY - 2014/9
Y1 - 2014/9
N2 - As the link between metabolism and major disease processes becomes more well-defined, the identification of key molecular targets is leading to new therapeutic strategies. As a result, small non-coding RNA molecules that regulate gene expression via epigenetic alterations, microRNAs have been identified as regulators of these metabolic processes. In the last decade, dietary interventions have been used to change metabolism and to potentially alter disease progression and clinical outcomes. These interventions have been linked, at a molecular level, to microRNAs. This review will summarize the role of various dietary strategies on the expression of several microRNA families.
AB - As the link between metabolism and major disease processes becomes more well-defined, the identification of key molecular targets is leading to new therapeutic strategies. As a result, small non-coding RNA molecules that regulate gene expression via epigenetic alterations, microRNAs have been identified as regulators of these metabolic processes. In the last decade, dietary interventions have been used to change metabolism and to potentially alter disease progression and clinical outcomes. These interventions have been linked, at a molecular level, to microRNAs. This review will summarize the role of various dietary strategies on the expression of several microRNA families.
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U2 - 10.1016/j.arr.2014.04.005
DO - 10.1016/j.arr.2014.04.005
M3 - Review article
C2 - 24833329
AN - SCOPUS:84906349862
VL - 17
SP - 16
EP - 24
JO - Ageing Research Reviews
JF - Ageing Research Reviews
SN - 1568-1637
ER -