MicroRNA in ovarian function

S. W. Maalouf, Wansheng Liu, Joy Lee Pate

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

The mammalian ovary is a dynamic organ. The coordination of follicle recruitment, selection, and ovulation and the timely development and regression of the corpus luteum are essential for a functional ovary and fertility. Deregulation of any of these processes results in ovarian dysfunction and potential infertility. MicroRNA (miRNA) are short noncoding RNA that regulate developmental processes and time-sensitive functions. The expression of miRNA in the ovary varies with cell type, function, and stage of the estrous cycle. miRNA are involved in the formation of primordial follicles, follicular recruitment and selection, follicular atresia, oocyte-cumulus cell interaction, granulosal cell function, and luteinization. miRNA are differentially expressed in luteal cells at the various stages of the estrous cycle and during maternal recognition of pregnancy, suggesting a role in luteal development, maintenance, and regression. An understanding of the patterns of expression and functions of miRNA in the ovary will lead to novel therapeutics to treat ovarian dysfunction and improve fertility and, potentially, to the development of better contraceptives.

Original languageEnglish (US)
Pages (from-to)7-18
Number of pages12
JournalCell And Tissue Research
Volume363
Issue number1
DOIs
StatePublished - Jan 1 2016

Fingerprint

MicroRNAs
Ovary
Luteolysis
Estrous Cycle
Fertility
Corpus Luteum Maintenance
Follicular Atresia
Luteinization
Cumulus Cells
Luteal Cells
Small Untranslated RNA
Contraceptive Agents
Ovulation
Cell Communication
Infertility
Oocytes
Mothers
Pregnancy
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

Cite this

Maalouf, S. W. ; Liu, Wansheng ; Pate, Joy Lee. / MicroRNA in ovarian function. In: Cell And Tissue Research. 2016 ; Vol. 363, No. 1. pp. 7-18.
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MicroRNA in ovarian function. / Maalouf, S. W.; Liu, Wansheng; Pate, Joy Lee.

In: Cell And Tissue Research, Vol. 363, No. 1, 01.01.2016, p. 7-18.

Research output: Contribution to journalReview article

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AU - Maalouf, S. W.

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AU - Pate, Joy Lee

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AB - The mammalian ovary is a dynamic organ. The coordination of follicle recruitment, selection, and ovulation and the timely development and regression of the corpus luteum are essential for a functional ovary and fertility. Deregulation of any of these processes results in ovarian dysfunction and potential infertility. MicroRNA (miRNA) are short noncoding RNA that regulate developmental processes and time-sensitive functions. The expression of miRNA in the ovary varies with cell type, function, and stage of the estrous cycle. miRNA are involved in the formation of primordial follicles, follicular recruitment and selection, follicular atresia, oocyte-cumulus cell interaction, granulosal cell function, and luteinization. miRNA are differentially expressed in luteal cells at the various stages of the estrous cycle and during maternal recognition of pregnancy, suggesting a role in luteal development, maintenance, and regression. An understanding of the patterns of expression and functions of miRNA in the ovary will lead to novel therapeutics to treat ovarian dysfunction and improve fertility and, potentially, to the development of better contraceptives.

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