MicroRNA miR-155 affects antiviral effector and effector memory CD8 T cell differentiation

Ching Yi Tsai, S. Rameeza Allie, Weijun Zhang, Edward J. Usherwood

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

MicroRNAs are key regulators of the immune response, but their role in CD8 T cell differentiation in vivo is not known. We show that miR-155 is important in both effector and memory antiviral CD8 T cell responses. Without miR-155, there was a weaker effector response and a skewing toward memory precursor cells. At the memory stage, miR-155-deficient CD8 T cells preferentially differentiated into central memory cells and were capable of mounting a potent secondary response.

Original languageEnglish (US)
Pages (from-to)2348-2351
Number of pages4
JournalJournal of virology
Volume87
Issue number4
DOIs
StatePublished - Feb 2013

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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