Microsatellite DNA variation and the evolution, domestication and phylogeography of taurine and zebu cattle (Bos taurus and Bos indicus)

David E. MacHugh, Mark Shriver, Ronan T. Loftus, Patrick Cunningham, Daniel G. Bradley

Research output: Contribution to journalArticle

344 Citations (Scopus)

Abstract

Genetic variation at 20 microsatellite loci was surveyed to determine the evolutionary relationships and molecular biogeography of 20 different cattle populations from Africa, Europe and Asia. Phylogenetic reconstruction and multivariate analysis highlighted a marked distinction between humpless (taurine) and humped (zebu) cattle, providing strong support for a separate origin for domesticated zebu cattle. A molecular clock calculation using bison (Bison sp.) as an outgroup gave an estimated divergence time between the two subspecies of 610,000-850,000 years. Substantial differences in the distribution of alleles at 10 of these loci were observed between zebu and taurine cattle. These markers subsequently proved very useful for investigations of gene flow and admixture in African populations. When these data we considered in conjunction with previous mitochondrial and Y chromosomal studies, a distinctive male-mediated pattern of zebu genetic introgression was revealed. The introgression of zebu-specific alleles in African cattle afforded a high resolution perspective on the hybrid culture nature of African cattle populations and also suggested that certain West African populations of valuable disease-tolerant taurine cattle are under threat of genetic absorption by migrating zebu herds.

Original languageEnglish (US)
Pages (from-to)1071-1086
Number of pages16
JournalGenetics
Volume146
Issue number3
StatePublished - Jul 23 1997

Fingerprint

Phylogeography
Taurine
Microsatellite Repeats
DNA
Bison
Domestication
Population
Alleles
Gene Flow

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

MacHugh, David E. ; Shriver, Mark ; Loftus, Ronan T. ; Cunningham, Patrick ; Bradley, Daniel G. / Microsatellite DNA variation and the evolution, domestication and phylogeography of taurine and zebu cattle (Bos taurus and Bos indicus). In: Genetics. 1997 ; Vol. 146, No. 3. pp. 1071-1086.
@article{1622306d6cb443e48189ec691752ed7a,
title = "Microsatellite DNA variation and the evolution, domestication and phylogeography of taurine and zebu cattle (Bos taurus and Bos indicus)",
abstract = "Genetic variation at 20 microsatellite loci was surveyed to determine the evolutionary relationships and molecular biogeography of 20 different cattle populations from Africa, Europe and Asia. Phylogenetic reconstruction and multivariate analysis highlighted a marked distinction between humpless (taurine) and humped (zebu) cattle, providing strong support for a separate origin for domesticated zebu cattle. A molecular clock calculation using bison (Bison sp.) as an outgroup gave an estimated divergence time between the two subspecies of 610,000-850,000 years. Substantial differences in the distribution of alleles at 10 of these loci were observed between zebu and taurine cattle. These markers subsequently proved very useful for investigations of gene flow and admixture in African populations. When these data we considered in conjunction with previous mitochondrial and Y chromosomal studies, a distinctive male-mediated pattern of zebu genetic introgression was revealed. The introgression of zebu-specific alleles in African cattle afforded a high resolution perspective on the hybrid culture nature of African cattle populations and also suggested that certain West African populations of valuable disease-tolerant taurine cattle are under threat of genetic absorption by migrating zebu herds.",
author = "MacHugh, {David E.} and Mark Shriver and Loftus, {Ronan T.} and Patrick Cunningham and Bradley, {Daniel G.}",
year = "1997",
month = "7",
day = "23",
language = "English (US)",
volume = "146",
pages = "1071--1086",
journal = "Genetics",
issn = "0016-6731",
publisher = "Genetics Society of America",
number = "3",

}

Microsatellite DNA variation and the evolution, domestication and phylogeography of taurine and zebu cattle (Bos taurus and Bos indicus). / MacHugh, David E.; Shriver, Mark; Loftus, Ronan T.; Cunningham, Patrick; Bradley, Daniel G.

In: Genetics, Vol. 146, No. 3, 23.07.1997, p. 1071-1086.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Microsatellite DNA variation and the evolution, domestication and phylogeography of taurine and zebu cattle (Bos taurus and Bos indicus)

AU - MacHugh, David E.

AU - Shriver, Mark

AU - Loftus, Ronan T.

AU - Cunningham, Patrick

AU - Bradley, Daniel G.

PY - 1997/7/23

Y1 - 1997/7/23

N2 - Genetic variation at 20 microsatellite loci was surveyed to determine the evolutionary relationships and molecular biogeography of 20 different cattle populations from Africa, Europe and Asia. Phylogenetic reconstruction and multivariate analysis highlighted a marked distinction between humpless (taurine) and humped (zebu) cattle, providing strong support for a separate origin for domesticated zebu cattle. A molecular clock calculation using bison (Bison sp.) as an outgroup gave an estimated divergence time between the two subspecies of 610,000-850,000 years. Substantial differences in the distribution of alleles at 10 of these loci were observed between zebu and taurine cattle. These markers subsequently proved very useful for investigations of gene flow and admixture in African populations. When these data we considered in conjunction with previous mitochondrial and Y chromosomal studies, a distinctive male-mediated pattern of zebu genetic introgression was revealed. The introgression of zebu-specific alleles in African cattle afforded a high resolution perspective on the hybrid culture nature of African cattle populations and also suggested that certain West African populations of valuable disease-tolerant taurine cattle are under threat of genetic absorption by migrating zebu herds.

AB - Genetic variation at 20 microsatellite loci was surveyed to determine the evolutionary relationships and molecular biogeography of 20 different cattle populations from Africa, Europe and Asia. Phylogenetic reconstruction and multivariate analysis highlighted a marked distinction between humpless (taurine) and humped (zebu) cattle, providing strong support for a separate origin for domesticated zebu cattle. A molecular clock calculation using bison (Bison sp.) as an outgroup gave an estimated divergence time between the two subspecies of 610,000-850,000 years. Substantial differences in the distribution of alleles at 10 of these loci were observed between zebu and taurine cattle. These markers subsequently proved very useful for investigations of gene flow and admixture in African populations. When these data we considered in conjunction with previous mitochondrial and Y chromosomal studies, a distinctive male-mediated pattern of zebu genetic introgression was revealed. The introgression of zebu-specific alleles in African cattle afforded a high resolution perspective on the hybrid culture nature of African cattle populations and also suggested that certain West African populations of valuable disease-tolerant taurine cattle are under threat of genetic absorption by migrating zebu herds.

UR - http://www.scopus.com/inward/record.url?scp=0030822807&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030822807&partnerID=8YFLogxK

M3 - Article

C2 - 9215909

AN - SCOPUS:0030822807

VL - 146

SP - 1071

EP - 1086

JO - Genetics

JF - Genetics

SN - 0016-6731

IS - 3

ER -