Microsatellite instability analysis of primary human brain tumors

Jiguang Zhu, Shang Zhi Guo, Alan H. Beggs, Takashi Maruyama, Tomas Santarius, Kathy Dashner, Nancy Olsen, Julian K. Wu, Peter Black

Research output: Contribution to journalArticle

51 Scopus citations

Abstract

Microsatellite instability, as shown by the presence of additional alleles or shifts of electrophoretic mobility at simple sequence tandem repeat loci, has been demonstrated in hereditary and sporadic colorectal tumors and many other tumor types. To study microsatellite instability in human brain tumors, we examined a total of 144 sporadic neoplasms. These included 33 astrocytic tumors, 23 oligodendrogliomas, six gangliogliomas, 41 meningiomas, 10 vestibular schwannomas and 31 pituitary adenomas. Di-, tri- and tetranucleotide repeat microsatellite markers localized on chromosome 4 and 9, X, 13 and 22, respectively, were used to assess whether instability was a significant aspect of their abnormal chromosomal pattern. Instability of microsatellite markers was detected in four oligodendrogliomas (17.4%), one pituitary adenoma (3.2%), one meningioma (2.4%), one astrocytic tumor (3.0%) and not at all in gangliogliomas and schwannomas. Therefore, our results suggest that the microsatellite instability which occurs in colorectal cancers with defective mismatch repair is infrequent in many types of human brain tumors and that the lower level of instability observed in brain tumors may be reflective of other mechanisms of genetic instability.

Original languageEnglish (US)
Pages (from-to)1417-1423
Number of pages7
JournalOncogene
Volume12
Issue number7
StatePublished - May 13 1996

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

Fingerprint Dive into the research topics of 'Microsatellite instability analysis of primary human brain tumors'. Together they form a unique fingerprint.

  • Cite this

    Zhu, J., Guo, S. Z., Beggs, A. H., Maruyama, T., Santarius, T., Dashner, K., Olsen, N., Wu, J. K., & Black, P. (1996). Microsatellite instability analysis of primary human brain tumors. Oncogene, 12(7), 1417-1423.