Microscopic Ultrasound Stimulation of Neural Tissue

Hesam Sadeghi Gougheri, Mehdi Kiani

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

Transcranial focused ultrasound has recently been studied as a promising noninvasive neuromodulation technology to stimulate deep brain regions with higher spatial resolution of sub-centimeter (cm) scale, compared with its noninvasive counterparts. In this paper, we propose the concept of microscopic ultrasound stimulation (μUS) in that miniaturized ultrasound transducers can be implanted in the neural (e.g. brain) tissue or on its surface to provide local ultrasound pressure intensities with sub-millimeter (mm) spatial resolution. Using finite-element simulations, we have studied the effects of diameter (0.2-4.5 mm), thickness (0.2-0.5 mm), and sonication frequency (0.5-5 MHz) of a disk-shaped piezoelectric transducer on its resulting acoustic beam profile. Since the focal zone of an ultrasound transducer is scaled down by its size, our results demonstrate the promising spatial resolution of hundreds of micrometers scale using μUS method.

Original languageEnglish (US)
Title of host publication2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018 - Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781538636039
DOIs
StatePublished - Dec 20 2018
Event2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018 - Cleveland, United States
Duration: Oct 17 2018Oct 19 2018

Other

Other2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018
CountryUnited States
CityCleveland
Period10/17/1810/19/18

All Science Journal Classification (ASJC) codes

  • Electrical and Electronic Engineering
  • Health Informatics
  • Instrumentation
  • Signal Processing
  • Biomedical Engineering

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  • Cite this

    Gougheri, H. S., & Kiani, M. (2018). Microscopic Ultrasound Stimulation of Neural Tissue. In 2018 IEEE Biomedical Circuits and Systems Conference, BioCAS 2018 - Proceedings [8584692] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/BIOCAS.2018.8584692