Microstructure of trabecular bone in a mouse model for down syndrome

Trish Parsons, Timothy Michael Ryan, Roger H. Reeves, Joan Therese Richtsmeier

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Down syndrome (DS) is caused by trisomy of human chromosome 21 (Hsa21) and results in a suite of dysmorphic phenotypes, including effects on the postcranial skeleton and the skull. We have previously demonstrated parallels in the patterns of craniofacial dysmorphology in DS and in the Ts65Dn mouse model for DS. The specific mechanisms underlying the production of these changes in craniofacial shape remain unknown. High-resolution computed tomography scan data were collected for the presphenoid bone of euploid and aneuploid mice. Three-dimensional morphometric parameters of trabecular bone were quantified and compared between euploid and aneuploid mice using nonparametric statistical tests. Aneuploid presphenoid bones were smaller than those of their euploid littermates and had lower bone volume fraction and fewer, more rod-like trabeculae. The differences in cancellous bone structure suggest that bone development, perhaps including bone modeling and remodeling, is affected by aneuploidy. These differences may contribute to the observed dysmorphology of skull and postcranial skeletal phenotypes in DS.

Original languageEnglish (US)
Pages (from-to)414-421
Number of pages8
JournalAnatomical Record
Volume290
Issue number4
DOIs
StatePublished - Apr 1 2007

Fingerprint

Down syndrome
Aneuploidy
Down Syndrome
microstructure
bone
animal models
aneuploidy
bones
Skull
Bone and Bones
Phenotype
skull
Chromosomes, Human, Pair 21
Bone Remodeling
Bone Development
Trisomy
Human Chromosomes
phenotype
Skeleton
trisomics

All Science Journal Classification (ASJC) codes

  • Anatomy
  • Biotechnology
  • Histology
  • Ecology, Evolution, Behavior and Systematics

Cite this

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Microstructure of trabecular bone in a mouse model for down syndrome. / Parsons, Trish; Ryan, Timothy Michael; Reeves, Roger H.; Richtsmeier, Joan Therese.

In: Anatomical Record, Vol. 290, No. 4, 01.04.2007, p. 414-421.

Research output: Contribution to journalArticle

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