Microwave-assisted suzuki cross-coupling reaction, a key step in the synthesis of polycyclic aromatic hydrocarbons and their metabolites

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Abstract

(Chemical Equation Presented) A highly efficient and general method for Suzuki cross-coupling reaction en route to the synthesis of polycyclic aromatic hydrocarbons (PAHs) and their metabolites has been developed. Microwave irradiation of aryl bromides 1 and boronic acids (2 and 3) using polyurea microencapsulated palladium catalyst (Pd EnCat 30) gave the coupling adducts 4 and 5 in excellent yields in just 20 min compared to ∼24 h under thermal conditions, corresponding to a ∼72-fold increase in reaction rate.

Original languageEnglish (US)
Pages (from-to)8987-8989
Number of pages3
JournalJournal of Organic Chemistry
Volume72
Issue number23
DOIs
StatePublished - Nov 9 2007

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

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