Microwave-assisted suzuki cross-coupling reaction, a key step in the synthesis of polycyclic aromatic hydrocarbons and their metabolites

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Abstract

(Chemical Equation Presented) A highly efficient and general method for Suzuki cross-coupling reaction en route to the synthesis of polycyclic aromatic hydrocarbons (PAHs) and their metabolites has been developed. Microwave irradiation of aryl bromides 1 and boronic acids (2 and 3) using polyurea microencapsulated palladium catalyst (Pd EnCat 30) gave the coupling adducts 4 and 5 in excellent yields in just 20 min compared to ∼24 h under thermal conditions, corresponding to a ∼72-fold increase in reaction rate.

Original languageEnglish (US)
Pages (from-to)8987-8989
Number of pages3
JournalJournal of Organic Chemistry
Volume72
Issue number23
DOIs
StatePublished - Nov 9 2007

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Boronic Acids
Microwave irradiation
Polycyclic Aromatic Hydrocarbons
Palladium
Metabolites
Bromides
Reaction rates
Microwaves
Catalysts
Hot Temperature
polyurea

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

Cite this

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abstract = "(Chemical Equation Presented) A highly efficient and general method for Suzuki cross-coupling reaction en route to the synthesis of polycyclic aromatic hydrocarbons (PAHs) and their metabolites has been developed. Microwave irradiation of aryl bromides 1 and boronic acids (2 and 3) using polyurea microencapsulated palladium catalyst (Pd EnCat 30) gave the coupling adducts 4 and 5 in excellent yields in just 20 min compared to ∼24 h under thermal conditions, corresponding to a ∼72-fold increase in reaction rate.",
author = "Sharma, {Arun K.} and Krishnegowda Gowdahalli and Jacek Krzeminski and Shantu Amin",
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language = "English (US)",
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AU - Sharma, Arun K.

AU - Gowdahalli, Krishnegowda

AU - Krzeminski, Jacek

AU - Amin, Shantu

PY - 2007/11/9

Y1 - 2007/11/9

N2 - (Chemical Equation Presented) A highly efficient and general method for Suzuki cross-coupling reaction en route to the synthesis of polycyclic aromatic hydrocarbons (PAHs) and their metabolites has been developed. Microwave irradiation of aryl bromides 1 and boronic acids (2 and 3) using polyurea microencapsulated palladium catalyst (Pd EnCat 30) gave the coupling adducts 4 and 5 in excellent yields in just 20 min compared to ∼24 h under thermal conditions, corresponding to a ∼72-fold increase in reaction rate.

AB - (Chemical Equation Presented) A highly efficient and general method for Suzuki cross-coupling reaction en route to the synthesis of polycyclic aromatic hydrocarbons (PAHs) and their metabolites has been developed. Microwave irradiation of aryl bromides 1 and boronic acids (2 and 3) using polyurea microencapsulated palladium catalyst (Pd EnCat 30) gave the coupling adducts 4 and 5 in excellent yields in just 20 min compared to ∼24 h under thermal conditions, corresponding to a ∼72-fold increase in reaction rate.

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