TY - JOUR
T1 - Midazolam
T2 - Dose-response studies of effectiveness and rebound insomnia
AU - Kales, A.
AU - Soldatos, C. R.
AU - Bixler, E. O.
AU - Goff, P. J.
AU - Vela-Bueno, A.
PY - 1983
Y1 - 1983
N2 - Midazolam, an investigational hypnotic, was evaluated for effectiveness, side effects, and withdrawal phenomena in doses of 10, 20, and 30 mg in three separate sleep laboratory studies, each including 4 placebo-baseline nights, 7 drug nights, and 3 placebo-withdrawal nights. Only a slight to moderate degree of effectiveness was shown across the three doses; this effectiveness was much more pronounced during the first third of the night. There was no dose-response effect for effectiveness with either initial or continued drug administration. In general, there was less effectiveness on the last 3 drug nights, indicating a potential for the development of tolerance over a relatively short period of time. Following withdrawal there was a marked dose-related worsening of sleep above baseline levels (rebound insomnia).
AB - Midazolam, an investigational hypnotic, was evaluated for effectiveness, side effects, and withdrawal phenomena in doses of 10, 20, and 30 mg in three separate sleep laboratory studies, each including 4 placebo-baseline nights, 7 drug nights, and 3 placebo-withdrawal nights. Only a slight to moderate degree of effectiveness was shown across the three doses; this effectiveness was much more pronounced during the first third of the night. There was no dose-response effect for effectiveness with either initial or continued drug administration. In general, there was less effectiveness on the last 3 drug nights, indicating a potential for the development of tolerance over a relatively short period of time. Following withdrawal there was a marked dose-related worsening of sleep above baseline levels (rebound insomnia).
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U2 - 10.1159/000137795
DO - 10.1159/000137795
M3 - Article
C2 - 6132414
AN - SCOPUS:0020700640
VL - 26
SP - 138
EP - 149
JO - [No source information available]
JF - [No source information available]
SN - 0042-1215
IS - 3
ER -