Midazolam enhances the analgesic properties of dexmedetomidine in the rat

Christine A. Boehm, Elizabeth L. Carney, Ronald J. Tallarida, Ronald P. Wilson

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective To investigate the analgesic properties of different dose combinations of midazolam and dexmedetomidine administered intraperitoneally (IP) in the rat.Study design Prospective experimental trial.Animals Seventy adult male Sprague Dawley rats weighing 250-300 g.Methods Dexmedetomidine (D) 0.03, 0.06, 0.09, 0.12, 0.15, 0.18, 0.21 mg kg-1 and midazolam (M) 5, 10, 25, 50 mg kg-1 were administered IP, alone then in combinations ranging from 0.03 D:5 M to 0.18 D:30 M mg kg-1. Analgesia was evaluated using the tail-flick test at time 0 (before injection), 15, 30, 45, 60 and 75 minutes.Results Midazolam at all doses administered (5-50 mg kg-1) did not significantly change tail-flick latencies from baseline values whereas D showed clear dose-dependent increases in tail-flick latency for doses administered in the range of 0.03-0.18 mg kg-1. Tail-flick latencies in rats administered D + M combinations were significantly greater than D alone (p < 0.05).Conclusions A dose-related analgesic effect was demonstrated for D in the rat, which was enhanced by co-administration of M.Clinical relevance The combination of D + M administered IP to rats at doses of 0.12:20 and 0.09:15 mg kg-1 was shown to be a good combination to provide sedation/analgesia with a duration of action greater than 60 minutes. The onset of sedation was rapid (1-3 minutes), and onset of profound analgesia was reached within 5-10 minutes.

Original languageEnglish (US)
Pages (from-to)550-556
Number of pages7
JournalVeterinary Anaesthesia and Analgesia
Volume37
Issue number6
DOIs
StatePublished - Nov 2010

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dexmedetomidine
Dexmedetomidine
analgesic effect
Midazolam
Analgesics
Tail
Analgesia
analgesia
rats
tail
administered dose
sedation
dosage
Sprague Dawley Rats
Research Design
normal values
Prospective Studies
Injections
experimental design
injection

All Science Journal Classification (ASJC) codes

  • veterinary(all)

Cite this

Boehm, Christine A. ; Carney, Elizabeth L. ; Tallarida, Ronald J. ; Wilson, Ronald P. / Midazolam enhances the analgesic properties of dexmedetomidine in the rat. In: Veterinary Anaesthesia and Analgesia. 2010 ; Vol. 37, No. 6. pp. 550-556.
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abstract = "Objective To investigate the analgesic properties of different dose combinations of midazolam and dexmedetomidine administered intraperitoneally (IP) in the rat.Study design Prospective experimental trial.Animals Seventy adult male Sprague Dawley rats weighing 250-300 g.Methods Dexmedetomidine (D) 0.03, 0.06, 0.09, 0.12, 0.15, 0.18, 0.21 mg kg-1 and midazolam (M) 5, 10, 25, 50 mg kg-1 were administered IP, alone then in combinations ranging from 0.03 D:5 M to 0.18 D:30 M mg kg-1. Analgesia was evaluated using the tail-flick test at time 0 (before injection), 15, 30, 45, 60 and 75 minutes.Results Midazolam at all doses administered (5-50 mg kg-1) did not significantly change tail-flick latencies from baseline values whereas D showed clear dose-dependent increases in tail-flick latency for doses administered in the range of 0.03-0.18 mg kg-1. Tail-flick latencies in rats administered D + M combinations were significantly greater than D alone (p < 0.05).Conclusions A dose-related analgesic effect was demonstrated for D in the rat, which was enhanced by co-administration of M.Clinical relevance The combination of D + M administered IP to rats at doses of 0.12:20 and 0.09:15 mg kg-1 was shown to be a good combination to provide sedation/analgesia with a duration of action greater than 60 minutes. The onset of sedation was rapid (1-3 minutes), and onset of profound analgesia was reached within 5-10 minutes.",
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Midazolam enhances the analgesic properties of dexmedetomidine in the rat. / Boehm, Christine A.; Carney, Elizabeth L.; Tallarida, Ronald J.; Wilson, Ronald P.

In: Veterinary Anaesthesia and Analgesia, Vol. 37, No. 6, 11.2010, p. 550-556.

Research output: Contribution to journalArticle

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N2 - Objective To investigate the analgesic properties of different dose combinations of midazolam and dexmedetomidine administered intraperitoneally (IP) in the rat.Study design Prospective experimental trial.Animals Seventy adult male Sprague Dawley rats weighing 250-300 g.Methods Dexmedetomidine (D) 0.03, 0.06, 0.09, 0.12, 0.15, 0.18, 0.21 mg kg-1 and midazolam (M) 5, 10, 25, 50 mg kg-1 were administered IP, alone then in combinations ranging from 0.03 D:5 M to 0.18 D:30 M mg kg-1. Analgesia was evaluated using the tail-flick test at time 0 (before injection), 15, 30, 45, 60 and 75 minutes.Results Midazolam at all doses administered (5-50 mg kg-1) did not significantly change tail-flick latencies from baseline values whereas D showed clear dose-dependent increases in tail-flick latency for doses administered in the range of 0.03-0.18 mg kg-1. Tail-flick latencies in rats administered D + M combinations were significantly greater than D alone (p < 0.05).Conclusions A dose-related analgesic effect was demonstrated for D in the rat, which was enhanced by co-administration of M.Clinical relevance The combination of D + M administered IP to rats at doses of 0.12:20 and 0.09:15 mg kg-1 was shown to be a good combination to provide sedation/analgesia with a duration of action greater than 60 minutes. The onset of sedation was rapid (1-3 minutes), and onset of profound analgesia was reached within 5-10 minutes.

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