Middle-aged men show higher sensitivity of sleep to the arousing effects of corticotropin-releasing hormone than young men

Clinical implications

Alexandros Vgontzas, Edward Bixler, Annmarie M. Wittman, Keith Zachman, Hung Mo Lin, Antonio Vela-Bueno, Anthony Kales, George P. Chrousos

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

The prevalence of insomnia associated with emotional stress increases markedly in middle-age. Both the top and end hormones of the hypothalamic-pituitary-adrenal axis, i.e. CRH and glucocorticoids, stimulate arousal/wakefulness and inhibit slow wave (deep) sleep in experimental animals and man. The objective of this study was to test the hypothesis that middle-age is characterized by increased sensitivity to the sleep-disturbing effects of the hypothalamic-pituitary-adrenal axis. We studied 12 healthy middle-aged (45.1 ± 4.9) and 12 healthy young (22.7 ± 2.8) men by monitoring their sleep by polysomnography for 4 consecutive nights, including in tandem i adaptation and 2 baseline nights and a night during which we administered equipotent doses of ovine CRH (1 μg/kg, iv bolus) 10 min after sleep onset. Analyses included comparisons within and between groups using multiple ANOVA and regression analysis. Although both middle-aged and young men responded to CRH with similar elevations of ACTH and cortisol, the former had significantly more wakefulness and suppression of slow wave sleep compared with baseline sleep; in contrast, the latter showed no change. Also, comparison of the change in sleep patterns from baseline to the CRH night in the young men to the respective change observed in middle-aged men showed that middle-age was associated with significantly higher wakefulness and significantly greater decrease in slow wave sleep than in young age. We conclude that middle-aged men show increased vulnerability of sleep to stress hormones, possibly resulting in impairments in the quality of sleep during periods of stress. We suggest that changes in sleep physiology associated with middle-age play a significant role in the marked increase of prevalence of insomnia in middle-age.

Original languageEnglish (US)
Pages (from-to)1489-1495
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume86
Issue number4
DOIs
StatePublished - Jan 1 2001

Fingerprint

Corticotropin-Releasing Hormone
Sleep
Wakefulness
Polysomnography
Sleep Initiation and Maintenance Disorders
Hypothalamic Hormones
Pituitary Hormones
Arousal
Physiology
Psychological Stress
Adrenocorticotropic Hormone
Analysis of variance (ANOVA)
Glucocorticoids
Regression analysis
Hydrocortisone
Sheep
Analysis of Variance
Animals
Regression Analysis
Hormones

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Vgontzas, Alexandros ; Bixler, Edward ; Wittman, Annmarie M. ; Zachman, Keith ; Lin, Hung Mo ; Vela-Bueno, Antonio ; Kales, Anthony ; Chrousos, George P. / Middle-aged men show higher sensitivity of sleep to the arousing effects of corticotropin-releasing hormone than young men : Clinical implications. In: Journal of Clinical Endocrinology and Metabolism. 2001 ; Vol. 86, No. 4. pp. 1489-1495.
@article{e8f40bd51e104be7a3f2095b112add39,
title = "Middle-aged men show higher sensitivity of sleep to the arousing effects of corticotropin-releasing hormone than young men: Clinical implications",
abstract = "The prevalence of insomnia associated with emotional stress increases markedly in middle-age. Both the top and end hormones of the hypothalamic-pituitary-adrenal axis, i.e. CRH and glucocorticoids, stimulate arousal/wakefulness and inhibit slow wave (deep) sleep in experimental animals and man. The objective of this study was to test the hypothesis that middle-age is characterized by increased sensitivity to the sleep-disturbing effects of the hypothalamic-pituitary-adrenal axis. We studied 12 healthy middle-aged (45.1 ± 4.9) and 12 healthy young (22.7 ± 2.8) men by monitoring their sleep by polysomnography for 4 consecutive nights, including in tandem i adaptation and 2 baseline nights and a night during which we administered equipotent doses of ovine CRH (1 μg/kg, iv bolus) 10 min after sleep onset. Analyses included comparisons within and between groups using multiple ANOVA and regression analysis. Although both middle-aged and young men responded to CRH with similar elevations of ACTH and cortisol, the former had significantly more wakefulness and suppression of slow wave sleep compared with baseline sleep; in contrast, the latter showed no change. Also, comparison of the change in sleep patterns from baseline to the CRH night in the young men to the respective change observed in middle-aged men showed that middle-age was associated with significantly higher wakefulness and significantly greater decrease in slow wave sleep than in young age. We conclude that middle-aged men show increased vulnerability of sleep to stress hormones, possibly resulting in impairments in the quality of sleep during periods of stress. We suggest that changes in sleep physiology associated with middle-age play a significant role in the marked increase of prevalence of insomnia in middle-age.",
author = "Alexandros Vgontzas and Edward Bixler and Wittman, {Annmarie M.} and Keith Zachman and Lin, {Hung Mo} and Antonio Vela-Bueno and Anthony Kales and Chrousos, {George P.}",
year = "2001",
month = "1",
day = "1",
doi = "10.1210/jcem.86.4.7370",
language = "English (US)",
volume = "86",
pages = "1489--1495",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "The Endocrine Society",
number = "4",

}

Middle-aged men show higher sensitivity of sleep to the arousing effects of corticotropin-releasing hormone than young men : Clinical implications. / Vgontzas, Alexandros; Bixler, Edward; Wittman, Annmarie M.; Zachman, Keith; Lin, Hung Mo; Vela-Bueno, Antonio; Kales, Anthony; Chrousos, George P.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 86, No. 4, 01.01.2001, p. 1489-1495.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Middle-aged men show higher sensitivity of sleep to the arousing effects of corticotropin-releasing hormone than young men

T2 - Clinical implications

AU - Vgontzas, Alexandros

AU - Bixler, Edward

AU - Wittman, Annmarie M.

AU - Zachman, Keith

AU - Lin, Hung Mo

AU - Vela-Bueno, Antonio

AU - Kales, Anthony

AU - Chrousos, George P.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - The prevalence of insomnia associated with emotional stress increases markedly in middle-age. Both the top and end hormones of the hypothalamic-pituitary-adrenal axis, i.e. CRH and glucocorticoids, stimulate arousal/wakefulness and inhibit slow wave (deep) sleep in experimental animals and man. The objective of this study was to test the hypothesis that middle-age is characterized by increased sensitivity to the sleep-disturbing effects of the hypothalamic-pituitary-adrenal axis. We studied 12 healthy middle-aged (45.1 ± 4.9) and 12 healthy young (22.7 ± 2.8) men by monitoring their sleep by polysomnography for 4 consecutive nights, including in tandem i adaptation and 2 baseline nights and a night during which we administered equipotent doses of ovine CRH (1 μg/kg, iv bolus) 10 min after sleep onset. Analyses included comparisons within and between groups using multiple ANOVA and regression analysis. Although both middle-aged and young men responded to CRH with similar elevations of ACTH and cortisol, the former had significantly more wakefulness and suppression of slow wave sleep compared with baseline sleep; in contrast, the latter showed no change. Also, comparison of the change in sleep patterns from baseline to the CRH night in the young men to the respective change observed in middle-aged men showed that middle-age was associated with significantly higher wakefulness and significantly greater decrease in slow wave sleep than in young age. We conclude that middle-aged men show increased vulnerability of sleep to stress hormones, possibly resulting in impairments in the quality of sleep during periods of stress. We suggest that changes in sleep physiology associated with middle-age play a significant role in the marked increase of prevalence of insomnia in middle-age.

AB - The prevalence of insomnia associated with emotional stress increases markedly in middle-age. Both the top and end hormones of the hypothalamic-pituitary-adrenal axis, i.e. CRH and glucocorticoids, stimulate arousal/wakefulness and inhibit slow wave (deep) sleep in experimental animals and man. The objective of this study was to test the hypothesis that middle-age is characterized by increased sensitivity to the sleep-disturbing effects of the hypothalamic-pituitary-adrenal axis. We studied 12 healthy middle-aged (45.1 ± 4.9) and 12 healthy young (22.7 ± 2.8) men by monitoring their sleep by polysomnography for 4 consecutive nights, including in tandem i adaptation and 2 baseline nights and a night during which we administered equipotent doses of ovine CRH (1 μg/kg, iv bolus) 10 min after sleep onset. Analyses included comparisons within and between groups using multiple ANOVA and regression analysis. Although both middle-aged and young men responded to CRH with similar elevations of ACTH and cortisol, the former had significantly more wakefulness and suppression of slow wave sleep compared with baseline sleep; in contrast, the latter showed no change. Also, comparison of the change in sleep patterns from baseline to the CRH night in the young men to the respective change observed in middle-aged men showed that middle-age was associated with significantly higher wakefulness and significantly greater decrease in slow wave sleep than in young age. We conclude that middle-aged men show increased vulnerability of sleep to stress hormones, possibly resulting in impairments in the quality of sleep during periods of stress. We suggest that changes in sleep physiology associated with middle-age play a significant role in the marked increase of prevalence of insomnia in middle-age.

UR - http://www.scopus.com/inward/record.url?scp=0035035002&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035035002&partnerID=8YFLogxK

U2 - 10.1210/jcem.86.4.7370

DO - 10.1210/jcem.86.4.7370

M3 - Article

VL - 86

SP - 1489

EP - 1495

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 4

ER -