TY - JOUR
T1 - Might cortical hyper-responsiveness in aging contribute to Alzheimer's disease?
AU - Jacob, Michael S.
AU - Duffy, Charles J.
N1 - Funding Information:
This work was supported by National Eye Institute (R01-EY022062, P30-EY01319), National Institute on Aging (R01-AG17596), Office of Naval Research (N000141110525), and University of Rochester Center for Translational Science (RR024135). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We gratefully acknowledge the scientific and computer programming contributions of William Vaughn and the assistance of Dr. Anthony Monacelli, Teresa Steffenella, and Eva Perelstein in recording sessions. We appreciate the comments of Dr. William K. Page, William Vaughn, and Colin Lockwood on earlier drafts of the manuscript. This work was supported by NEI R01-EY022062, NEI P30-EY01319, R01-NIA AG17596, ONR N000141110525, and UofR CTSI RR024135.
PY - 2014/9
Y1 - 2014/9
N2 - Our goal is to understand the neural basis of functional impairment in aging and Alzheimer's disease (AD) to be able to characterize clinically significant decline and assess therapeutic efficacy. We used frequency-tagged ERPs to word and motion stimuli to study the effects of stimulus conditions and selective attention. ERPs to word or motion increase when a task-irrelevant 2nd stimulus is added, but decrease when the task is moved to that 2nd stimulus. Spectral analyses show task effects on response power without 2nd stimulus effects. However, phase coherence shows both 2nd stimulus and task effects. Thus, power and coherence are dissociably modulated by stimulus and task effects. Task-dependent phase coherence successively declines in aging and AD. In contrast, task-dependent spectral power increases in aging, only to decrease in AD. We hypothesize that age-related declines in signal coherence, associated with increased power generation, stresses neurons and contributes to the loss of response power and the development of functional impairment in AD.
AB - Our goal is to understand the neural basis of functional impairment in aging and Alzheimer's disease (AD) to be able to characterize clinically significant decline and assess therapeutic efficacy. We used frequency-tagged ERPs to word and motion stimuli to study the effects of stimulus conditions and selective attention. ERPs to word or motion increase when a task-irrelevant 2nd stimulus is added, but decrease when the task is moved to that 2nd stimulus. Spectral analyses show task effects on response power without 2nd stimulus effects. However, phase coherence shows both 2nd stimulus and task effects. Thus, power and coherence are dissociably modulated by stimulus and task effects. Task-dependent phase coherence successively declines in aging and AD. In contrast, task-dependent spectral power increases in aging, only to decrease in AD. We hypothesize that age-related declines in signal coherence, associated with increased power generation, stresses neurons and contributes to the loss of response power and the development of functional impairment in AD.
UR - http://www.scopus.com/inward/record.url?scp=84960154100&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84960154100&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0105962
DO - 10.1371/journal.pone.0105962
M3 - Article
C2 - 25208332
AN - SCOPUS:84960154100
VL - 9
JO - PLoS One
JF - PLoS One
SN - 1932-6203
IS - 9
M1 - e105962
ER -