Migration and persistence of human influenza A viruses, Vietnam, 2001-2008

Mai Quynh Le, Ha Minh Lam, Vuong Duc Cuong, Tommy Tsan Yuk Lam, Rebecca A. Halpin, David E. Wentworth, Nguyen Tran Hien, Le Thi Thanh, Hoang Vu Mai Phuong, Peter Horby, Maciej F. Boni

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Understanding global influenza migration and persistence is crucial for vaccine strain selection. Using 240 new human influenza A virus whole genomes collected in Vietnam during 2001-2008, we looked for persistence patterns and migratory connections between Vietnam and other countries. We found that viruses in Vietnam migrate to and from China, Hong Kong, Taiwan, Cambodia, Japan, South Korea, and the United States. We attempted to reduce geographic bias by generating phylogenies subsampled at the year and country levels. However, migration events in these phylogenies were still driven by the presence or absence of sequence data, indicating that an epidemiologic study design that controls for prevalence is required for robust migration analysis. With whole-genome data, most migration events are not detectable from the phylogeny of the hemagglutinin segment alone, although general migratory relationships between Vietnam and other countries are visible in the hemagglutinin phylogeny. It is possible that virus lineages in Vietnam persisted for >1 year.

Original languageEnglish (US)
Pages (from-to)1756-1765
Number of pages10
JournalEmerging infectious diseases
Volume19
Issue number11
DOIs
StatePublished - Nov 1 2013

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Vietnam
Influenza A virus
Human Influenza
Phylogeny
Hemagglutinins
Genome
Cambodia
Viruses
Republic of Korea
Hong Kong
Taiwan
Epidemiologic Studies
China
Japan
Vaccines

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Le, M. Q., Lam, H. M., Cuong, V. D., Lam, T. T. Y., Halpin, R. A., Wentworth, D. E., ... Boni, M. F. (2013). Migration and persistence of human influenza A viruses, Vietnam, 2001-2008. Emerging infectious diseases, 19(11), 1756-1765. https://doi.org/10.3201/eid1911.130349
Le, Mai Quynh ; Lam, Ha Minh ; Cuong, Vuong Duc ; Lam, Tommy Tsan Yuk ; Halpin, Rebecca A. ; Wentworth, David E. ; Hien, Nguyen Tran ; Thanh, Le Thi ; Phuong, Hoang Vu Mai ; Horby, Peter ; Boni, Maciej F. / Migration and persistence of human influenza A viruses, Vietnam, 2001-2008. In: Emerging infectious diseases. 2013 ; Vol. 19, No. 11. pp. 1756-1765.
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Le, MQ, Lam, HM, Cuong, VD, Lam, TTY, Halpin, RA, Wentworth, DE, Hien, NT, Thanh, LT, Phuong, HVM, Horby, P & Boni, MF 2013, 'Migration and persistence of human influenza A viruses, Vietnam, 2001-2008', Emerging infectious diseases, vol. 19, no. 11, pp. 1756-1765. https://doi.org/10.3201/eid1911.130349

Migration and persistence of human influenza A viruses, Vietnam, 2001-2008. / Le, Mai Quynh; Lam, Ha Minh; Cuong, Vuong Duc; Lam, Tommy Tsan Yuk; Halpin, Rebecca A.; Wentworth, David E.; Hien, Nguyen Tran; Thanh, Le Thi; Phuong, Hoang Vu Mai; Horby, Peter; Boni, Maciej F.

In: Emerging infectious diseases, Vol. 19, No. 11, 01.11.2013, p. 1756-1765.

Research output: Contribution to journalArticle

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Le MQ, Lam HM, Cuong VD, Lam TTY, Halpin RA, Wentworth DE et al. Migration and persistence of human influenza A viruses, Vietnam, 2001-2008. Emerging infectious diseases. 2013 Nov 1;19(11):1756-1765. https://doi.org/10.3201/eid1911.130349