Migration and persistence of human influenza A viruses, Vietnam, 2001-2008

Mai Quynh Le, Ha Minh Lam, Vuong Duc Cuong, Tommy Tsan Yuk Lam, Rebecca A. Halpin, David E. Wentworth, Nguyen Tran Hien, Le Thi Thanh, Hoang Vu Mai Phuong, Peter Horby, Maciej F. Boni

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Understanding global influenza migration and persistence is crucial for vaccine strain selection. Using 240 new human influenza A virus whole genomes collected in Vietnam during 2001-2008, we looked for persistence patterns and migratory connections between Vietnam and other countries. We found that viruses in Vietnam migrate to and from China, Hong Kong, Taiwan, Cambodia, Japan, South Korea, and the United States. We attempted to reduce geographic bias by generating phylogenies subsampled at the year and country levels. However, migration events in these phylogenies were still driven by the presence or absence of sequence data, indicating that an epidemiologic study design that controls for prevalence is required for robust migration analysis. With whole-genome data, most migration events are not detectable from the phylogeny of the hemagglutinin segment alone, although general migratory relationships between Vietnam and other countries are visible in the hemagglutinin phylogeny. It is possible that virus lineages in Vietnam persisted for >1 year.

Original languageEnglish (US)
Pages (from-to)1756-1765
Number of pages10
JournalEmerging infectious diseases
Issue number11
StatePublished - Nov 2013

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases


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