Migration of implanted free radioactive seeds for adenocarcinoma of the prostate using a Mick applicator

Charles A. Kunos, Martin I. Resnick, Timothy J. Kinsella, Rodney J. Ellis

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

This study investigates the rate of free seed migration and associated seed-related sequelae after using a radioimmunoguided Mick applicator technique to place radioactive seeds within the prostate.Between December 1998 and September 2002, 120 patients diagnosed with prostate cancer underwent interstitial transperineal prostate brachytherapy with free 125I or 103Pd seeds positioned using a radioimmunoguided Mick applicator technique. Orthogonal pelvic and chest radiographs were obtained postimplant (Day 0) and at a second follow-up visit to determine the rate of radioactive seed embolization.On the day of implant (Day 0), 7 (6%) of the 120 men demonstrated single pulmonary seed emboli; none of these seeds migrated subsequently. During follow-up, 87 (72.5%) men had a total of 249 (2.0%) out of 12,524 seeds implanted migrate. Sixty-eight (0.55%) of the implanted seeds migrated to the lungs, an incidence common among brachytherapy techniques utilizing free or vicryl-laden radioactive seeds. No clinical symptoms or adverse sequelae from seed emboli have been reported.The rate of seed emboli to the pulmonary vessels or to other tissue localities resulting from a radioimmunoguided Mick applicator technique does not appear to be markedly different from the reported rate seen with other free seed techniques.

Original languageEnglish (US)
Pages (from-to)71-77
Number of pages7
JournalBrachytherapy
Volume3
Issue number2
DOIs
StatePublished - Sep 1 2004

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging

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