Milk and serum standard reference materials for monitoring organic contaminants in human samples

Michele M. Schantz, Gauthier Eppe, Jean François Focant, Coreen Hamilton, N. Alan Heckert, Rebecca M. Heltsley, Dale Hoover, Jennifer M. Keller, Stefan D. Leigh, Donald G. Patterson, Adam L. Pintar, Katherine E. Sharpless, Andreas Sjödin, Wayman E. Turner, Stacy S. Vander Pol, Stephen A. Wise

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Four new Standard Reference Materials (SRMs) have been developed to assist in the quality assurance of chemical contaminant measurements required for human biomonitoring studies, SRM 1953 Organic Contaminants in Non-Fortified Human Milk, SRM 1954 Organic Contaminants in Fortified Human Milk, SRM 1957 Organic Contaminants in Non-Fortified Human Serum, and SRM 1958 Organic Contaminants in Fortified Human Serum. These materials were developed as part of a collaboration between the National Institute of Standards and Technology (NIST) and the Centers for Disease Control and Prevention (CDC) with both agencies contributing data used in the certification of mass fraction values for a wide range of organic contaminants including polychlorinated biphenyl (PCB) congeners, chlorinated pesticides, polybrominated diphenyl ether (PBDE) congeners, and polychlorinated dibenzo-p-dioxin (PCDD) and dibenzofuran (PCDF) congeners. The certified mass fractions of the organic contaminants in unfortified samples, SRM 1953 and SRM 1957, ranged from 12 ng/kg to 2200 ng/kg with the exception of 4,4′-DDE in SRM 1953 at 7400 ng/kg with expanded uncertainties generally <14 %. This agreement suggests that there were no significant biases existing among the multiple methods used for analysis.

Original languageEnglish (US)
Pages (from-to)1203-1211
Number of pages9
JournalAnalytical and Bioanalytical Chemistry
Volume405
Issue number4
DOIs
StatePublished - Jan 1 2013

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry

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    Schantz, M. M., Eppe, G., Focant, J. F., Hamilton, C., Heckert, N. A., Heltsley, R. M., Hoover, D., Keller, J. M., Leigh, S. D., Patterson, D. G., Pintar, A. L., Sharpless, K. E., Sjödin, A., Turner, W. E., Vander Pol, S. S., & Wise, S. A. (2013). Milk and serum standard reference materials for monitoring organic contaminants in human samples. Analytical and Bioanalytical Chemistry, 405(4), 1203-1211. https://doi.org/10.1007/s00216-012-6524-3