Milk-borne prolactin and neonatal development.

L. A. Ellis, Andrea Marie Mastro, M. F. Picciano

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

Milk is primarily regarded as a food furnishing essential nutrients for infant growth and development, but milk can also serve as a vehicle for mother to neonate transfer of molecules that regulate development. A wide array of biologically active compounds such as hormones, cytokines and enzymes are present in milk, especially early milk. The premise that prolactin (PRL) in milk is an important and possibly essential developmental factor for the newborn is explored. Both PRL and structurally modified isoforms are abundant in early milk and gradually diminish with the progression of lactation. Milk PRL is absorbed and biologically active in the neonate. Assays of PRL variants, experimental paradigms to test them as developmental regulators and the body of evidence supporting the hypothesis that milk PRL regulates differentiation and maturation of neonatal neuroendocrine, reproductive, and immune systems is presented.

Original languageEnglish (US)
Pages (from-to)259-269
Number of pages11
JournalJournal of Mammary Gland Biology and Neoplasia
Volume1
Issue number3
DOIs
StatePublished - Jan 1 1996

Fingerprint

Prolactin
Milk
Food
Neurosecretory Systems
Child Development
Growth and Development
Lactation
Immune System
Protein Isoforms
Hormones
Cytokines
Enzymes

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Ellis, L. A. ; Mastro, Andrea Marie ; Picciano, M. F. / Milk-borne prolactin and neonatal development. In: Journal of Mammary Gland Biology and Neoplasia. 1996 ; Vol. 1, No. 3. pp. 259-269.
@article{d0e323ff6c70429fa64a169aedae0ecc,
title = "Milk-borne prolactin and neonatal development.",
abstract = "Milk is primarily regarded as a food furnishing essential nutrients for infant growth and development, but milk can also serve as a vehicle for mother to neonate transfer of molecules that regulate development. A wide array of biologically active compounds such as hormones, cytokines and enzymes are present in milk, especially early milk. The premise that prolactin (PRL) in milk is an important and possibly essential developmental factor for the newborn is explored. Both PRL and structurally modified isoforms are abundant in early milk and gradually diminish with the progression of lactation. Milk PRL is absorbed and biologically active in the neonate. Assays of PRL variants, experimental paradigms to test them as developmental regulators and the body of evidence supporting the hypothesis that milk PRL regulates differentiation and maturation of neonatal neuroendocrine, reproductive, and immune systems is presented.",
author = "Ellis, {L. A.} and Mastro, {Andrea Marie} and Picciano, {M. F.}",
year = "1996",
month = "1",
day = "1",
doi = "10.1007/BF02018079",
language = "English (US)",
volume = "1",
pages = "259--269",
journal = "Journal of Mammary Gland Biology and Neoplasia",
issn = "1083-3021",
publisher = "Springer New York",
number = "3",

}

Milk-borne prolactin and neonatal development. / Ellis, L. A.; Mastro, Andrea Marie; Picciano, M. F.

In: Journal of Mammary Gland Biology and Neoplasia, Vol. 1, No. 3, 01.01.1996, p. 259-269.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Milk-borne prolactin and neonatal development.

AU - Ellis, L. A.

AU - Mastro, Andrea Marie

AU - Picciano, M. F.

PY - 1996/1/1

Y1 - 1996/1/1

N2 - Milk is primarily regarded as a food furnishing essential nutrients for infant growth and development, but milk can also serve as a vehicle for mother to neonate transfer of molecules that regulate development. A wide array of biologically active compounds such as hormones, cytokines and enzymes are present in milk, especially early milk. The premise that prolactin (PRL) in milk is an important and possibly essential developmental factor for the newborn is explored. Both PRL and structurally modified isoforms are abundant in early milk and gradually diminish with the progression of lactation. Milk PRL is absorbed and biologically active in the neonate. Assays of PRL variants, experimental paradigms to test them as developmental regulators and the body of evidence supporting the hypothesis that milk PRL regulates differentiation and maturation of neonatal neuroendocrine, reproductive, and immune systems is presented.

AB - Milk is primarily regarded as a food furnishing essential nutrients for infant growth and development, but milk can also serve as a vehicle for mother to neonate transfer of molecules that regulate development. A wide array of biologically active compounds such as hormones, cytokines and enzymes are present in milk, especially early milk. The premise that prolactin (PRL) in milk is an important and possibly essential developmental factor for the newborn is explored. Both PRL and structurally modified isoforms are abundant in early milk and gradually diminish with the progression of lactation. Milk PRL is absorbed and biologically active in the neonate. Assays of PRL variants, experimental paradigms to test them as developmental regulators and the body of evidence supporting the hypothesis that milk PRL regulates differentiation and maturation of neonatal neuroendocrine, reproductive, and immune systems is presented.

UR - http://www.scopus.com/inward/record.url?scp=0030177001&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030177001&partnerID=8YFLogxK

U2 - 10.1007/BF02018079

DO - 10.1007/BF02018079

M3 - Review article

VL - 1

SP - 259

EP - 269

JO - Journal of Mammary Gland Biology and Neoplasia

JF - Journal of Mammary Gland Biology and Neoplasia

SN - 1083-3021

IS - 3

ER -