Millimeter scale alignment of magnetic nanoparticle functionalized microtubules in magnetic fields

Mark Platt, Gayatri Muthukrishnan, William O. Hancock, Mary Elizabeth Williams

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

The conjugation of 14 nm diameter CoFe2O4 nanoparticles to the surface of biotinylated microtubules enables their manipulation with externally applied magnetic fields of small, permanent NdFeB magnets. Microtubules are selectively patterned on kinesin motor-modified glass surfaces in coparallel arrays that mimic the orientation of the magnetic field lines over millimeter distances. The magnetic field is simultaneously used to increase surface loading of microtubules. We demonstrate that motility across the kinesin motor surface is retained following magnetic functionalization of the microtubules, while gliding speed is dependent on loading level of the neutravidin linker as well as magnetic nanoparticles.

Original languageEnglish (US)
Pages (from-to)15686-15687
Number of pages2
JournalJournal of the American Chemical Society
Volume127
Issue number45
DOIs
StatePublished - Nov 16 2005

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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