It is also important to establish a method to use alternative donors in mini-transplant settings. However, there are some problems, such as difficulty in performing donor-lymphocyte infusion(DLI) from an unrelated donor. In most countries including Japan, bone marrow is mostly used as a source of stem cells in unrelated transplant. This may cause another problem in engraftment. In addition, graft rejection and GVHD may also be a problem because of the difference in minor antigens. Despite these problems, early experience including our own has shown that mini-transplant from an unrelated donor is a feasible procedure and further development is expected.
|Original language||English (US)|
|Number of pages||4|
|Journal||Nippon rinsho. Japanese journal of clinical medicine|
|State||Published - Jan 1 2003|
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