This study proposes a novel concept for a three-axis positioning and scanning platform that overcomes the existing gap in technology towards meeting the requirements for displacements, resolution, weight carrying capacity and velocity at smaller dimensions. The novelty of this work stems from the fact that our three-axis stage design utilizes only two actuators. This system was developed to meet the specific requirements needed for implementation of Multifunctional Image Guided Surgical (MIGS) platform. Mathematical model accounting for the open and closed loop operation of the stage was developed. The stage can provide displacements between 10-20mm in each axis, resolution of less than 10μm and scanning velocity in the range of 10-40mm/s. It can carry weights up to 10grams while meeting the desired requirements. Additionally, the stage has small footprint (50mm x 50mm x 34mm), modular design and extremely cost-effective fabrication. Integration of computer controlled three-axis stage with MIGS platform will provide the opportunity for conducting intricate surgical procedures using remote control or joystick. We demonstrate novel applications that became possible due to the development of this stage.