3 Citations (Scopus)

Abstract

Crawling cell motility is vital to many biological processes such as wound healing and the immune response. Using a minimal model we investigate the effects of patterned substrate adhesiveness and biophysical cell parameters on the direction of cell motion. We show that cells with low adhesion site formation rates may move perpendicular to adhesive stripes while those with high adhesion site formation rates results in motility only parallel to the substrate stripes. We explore the effects of varying the substrate pattern geometry and the strength of actin polymerization on the directionality of the crawling cell. These results reveal that high strength of actin polymerization results in motion perpendicular to substrate stripes only when the substrate is relatively nonadhesive; in particular, this suggests potential applications in motile cell sorting and guiding on engineered substrates.

Original languageEnglish (US)
Article number052408
JournalPhysical Review E
Volume96
Issue number5
DOIs
StatePublished - Nov 15 2017

Fingerprint

Cell Motility
locomotion
Minimal Model
Substrate
cells
Cell
Actin
Polymerization
Adhesion
Perpendicular
adhesion
polymerization
Wound Healing
wound healing
Motility
Motion
Immune Response
Adhesives
high strength
classifying

All Science Journal Classification (ASJC) codes

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics

Cite this

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title = "Minimal model of directed cell motility on patterned substrates",
abstract = "Crawling cell motility is vital to many biological processes such as wound healing and the immune response. Using a minimal model we investigate the effects of patterned substrate adhesiveness and biophysical cell parameters on the direction of cell motion. We show that cells with low adhesion site formation rates may move perpendicular to adhesive stripes while those with high adhesion site formation rates results in motility only parallel to the substrate stripes. We explore the effects of varying the substrate pattern geometry and the strength of actin polymerization on the directionality of the crawling cell. These results reveal that high strength of actin polymerization results in motion perpendicular to substrate stripes only when the substrate is relatively nonadhesive; in particular, this suggests potential applications in motile cell sorting and guiding on engineered substrates.",
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Minimal model of directed cell motility on patterned substrates. / Mizuhara, Matthew S.; Berlyand, Leonid; Aranson, Igor S.

In: Physical Review E, Vol. 96, No. 5, 052408, 15.11.2017.

Research output: Contribution to journalArticle

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T1 - Minimal model of directed cell motility on patterned substrates

AU - Mizuhara, Matthew S.

AU - Berlyand, Leonid

AU - Aranson, Igor S.

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N2 - Crawling cell motility is vital to many biological processes such as wound healing and the immune response. Using a minimal model we investigate the effects of patterned substrate adhesiveness and biophysical cell parameters on the direction of cell motion. We show that cells with low adhesion site formation rates may move perpendicular to adhesive stripes while those with high adhesion site formation rates results in motility only parallel to the substrate stripes. We explore the effects of varying the substrate pattern geometry and the strength of actin polymerization on the directionality of the crawling cell. These results reveal that high strength of actin polymerization results in motion perpendicular to substrate stripes only when the substrate is relatively nonadhesive; in particular, this suggests potential applications in motile cell sorting and guiding on engineered substrates.

AB - Crawling cell motility is vital to many biological processes such as wound healing and the immune response. Using a minimal model we investigate the effects of patterned substrate adhesiveness and biophysical cell parameters on the direction of cell motion. We show that cells with low adhesion site formation rates may move perpendicular to adhesive stripes while those with high adhesion site formation rates results in motility only parallel to the substrate stripes. We explore the effects of varying the substrate pattern geometry and the strength of actin polymerization on the directionality of the crawling cell. These results reveal that high strength of actin polymerization results in motion perpendicular to substrate stripes only when the substrate is relatively nonadhesive; in particular, this suggests potential applications in motile cell sorting and guiding on engineered substrates.

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