MiR-296 regulation of a cell polarity-cell plasticity module controls tumor progression

V. Vaira, A. Faversani, Takehiko Dohi, M. Montorsi, C. Augello, S. Gatti, G. Coggi, D. C. Altieri, S. Bosari

Research output: Contribution to journalArticle

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Abstract

The expression of small, non-coding RNA or microRNAs (miR), is frequently deregulated in human cancer, but how these pathways affect disease progression is still largely elusive. Here, we report on a miR, miR-296, which is progressively lost during tumor progression and correlates with metastatic disease in colorectal, breast, lung, gastric, parathyroid, liver and bile ducts cancers. Functionally, miR-296 controls a global cell motility gene signature in epithelial cells by transcriptionally repressing the cell polarity-cell plasticity module, Scribble (Scrib). In turn, loss of miR-296 causes aberrantly increased and mislocalized Scrib in human tumors, resulting in exaggerated random cell migration and tumor cell invasiveness. Re-expression of miR-296 in MDA-MB231 cells inhibits tumor growth in vivo. Finally, miR-296 or Scrib levels predict tumor relapse in hepatocellular carcinoma patients. These data identify miR-296 as a global repressor of tumorigenicity and uncover a previously unexplored exploitation of Scrib in tumor progression in humans.

Original languageEnglish (US)
Pages (from-to)27-38
Number of pages12
JournalOncogene
Volume31
Issue number1
DOIs
StatePublished - Jan 5 2012

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Cell Polarity
MicroRNAs
Neoplasms
Cell Movement
Bile Duct Neoplasms
Small Untranslated RNA
Cell Plasticity
Disease Progression
Hepatocellular Carcinoma
Stomach
Breast
Epithelial Cells
Recurrence
Lung
Liver
Growth

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Cancer Research

Cite this

Vaira, V., Faversani, A., Dohi, T., Montorsi, M., Augello, C., Gatti, S., ... Bosari, S. (2012). MiR-296 regulation of a cell polarity-cell plasticity module controls tumor progression. Oncogene, 31(1), 27-38. https://doi.org/10.1038/onc.2011.209
Vaira, V. ; Faversani, A. ; Dohi, Takehiko ; Montorsi, M. ; Augello, C. ; Gatti, S. ; Coggi, G. ; Altieri, D. C. ; Bosari, S. / MiR-296 regulation of a cell polarity-cell plasticity module controls tumor progression. In: Oncogene. 2012 ; Vol. 31, No. 1. pp. 27-38.
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Vaira, V, Faversani, A, Dohi, T, Montorsi, M, Augello, C, Gatti, S, Coggi, G, Altieri, DC & Bosari, S 2012, 'MiR-296 regulation of a cell polarity-cell plasticity module controls tumor progression', Oncogene, vol. 31, no. 1, pp. 27-38. https://doi.org/10.1038/onc.2011.209

MiR-296 regulation of a cell polarity-cell plasticity module controls tumor progression. / Vaira, V.; Faversani, A.; Dohi, Takehiko; Montorsi, M.; Augello, C.; Gatti, S.; Coggi, G.; Altieri, D. C.; Bosari, S.

In: Oncogene, Vol. 31, No. 1, 05.01.2012, p. 27-38.

Research output: Contribution to journalArticle

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AU - Augello, C.

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