MiR-877-3p targets Smad7 and is associated with myofibroblast differentiation and bleomycin-induced lung fibrosis

Cong Wang, Shen Gu, Honghui Cao, Zutong Li, Zou Xiang, Kebin Hu, Xiaodong Han

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

Myofibroblast differentiation of lung resident mesenchymal stem cells (LR-MSC) plays an important role in idiopathic pulmonary fibrosis. By comparing the expression profiles of miRNAs before and after myofibroblast differentiation of LR-MSC, we identified miR-877-3p as a fibrosis-related miRNA. We found that miR-877-3p sequestration inhibited the myofibroblast differentiation of LR-MSC and attenuates bleomycin-induced lung fibrosis by targeting Smad7. Smad7, as an inhibitory smad in the TGF-β1 signaling pathway, was decreased in the myofibroblast differentiation of LR-MSC and up-regulation of Smad7 could inhibit the differentiation process. Our data implicates a potential application of miR-877-3p as a fibrosis suppressor for pulmonary fibrosis therapy and also as a fibrosis marker for predicting prognosis.

Original languageEnglish (US)
Article number30122
JournalScientific reports
Volume6
DOIs
StatePublished - Jul 22 2016

All Science Journal Classification (ASJC) codes

  • General

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