Mitochondria-based aircraft carrier enhances in vivo imaging of carbon quantum dots and delivery of anticancer drug

Wen Qing Li, Zhigang Wang, Sijie Hao, Liping Sun, Merisa Nisic, Gong Cheng, Chuandong Zhu, Yuan Wan, Laura Ha, Si Yang Zheng

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The application of engineered bacteria-based drug delivery vehicles to treat cancer has been practiced for more than a century. Mitochondria, evolutionarily originated from bacteria, are ubiquitous, semi-autonomous cellular organelles. In this study, we present the first exploration of using mitochondria as a delivery system of carbon quantum dots (CQDs) for in vivo imaging and administration of the anticancer drug doxorubicin (DOX). The results show that mitochondria as carriers are compatible with CQD loading and preserve the optical properties of CQDs. Moreover, the mitochondria delivery system can improve the CQD bio-distribution in organs and prolong the retention time of CQDs after intravenous injection. Furthermore, mitochondria loaded with doxorubicin hydrochloride (Mito-DOX) show an enhanced therapeutic effect compared to free DOX. The mitochondria-based "aircraft" system may be a promising novel therapeutic platform with high potential for biological imaging and drug delivery to fight cancer and other diseases.

Original languageEnglish (US)
Pages (from-to)3744-3752
Number of pages9
JournalNanoscale
Volume10
Issue number8
DOIs
StatePublished - Feb 28 2018

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Aircraft carriers
Mitochondria
Semiconductor quantum dots
Carbon
Imaging techniques
Doxorubicin
Pharmaceutical Preparations
Drug delivery
Bacteria
Optical properties
Aircraft

All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

Li, W. Q., Wang, Z., Hao, S., Sun, L., Nisic, M., Cheng, G., ... Zheng, S. Y. (2018). Mitochondria-based aircraft carrier enhances in vivo imaging of carbon quantum dots and delivery of anticancer drug. Nanoscale, 10(8), 3744-3752. https://doi.org/10.1039/c7nr08816g
Li, Wen Qing ; Wang, Zhigang ; Hao, Sijie ; Sun, Liping ; Nisic, Merisa ; Cheng, Gong ; Zhu, Chuandong ; Wan, Yuan ; Ha, Laura ; Zheng, Si Yang. / Mitochondria-based aircraft carrier enhances in vivo imaging of carbon quantum dots and delivery of anticancer drug. In: Nanoscale. 2018 ; Vol. 10, No. 8. pp. 3744-3752.
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Li, WQ, Wang, Z, Hao, S, Sun, L, Nisic, M, Cheng, G, Zhu, C, Wan, Y, Ha, L & Zheng, SY 2018, 'Mitochondria-based aircraft carrier enhances in vivo imaging of carbon quantum dots and delivery of anticancer drug', Nanoscale, vol. 10, no. 8, pp. 3744-3752. https://doi.org/10.1039/c7nr08816g

Mitochondria-based aircraft carrier enhances in vivo imaging of carbon quantum dots and delivery of anticancer drug. / Li, Wen Qing; Wang, Zhigang; Hao, Sijie; Sun, Liping; Nisic, Merisa; Cheng, Gong; Zhu, Chuandong; Wan, Yuan; Ha, Laura; Zheng, Si Yang.

In: Nanoscale, Vol. 10, No. 8, 28.02.2018, p. 3744-3752.

Research output: Contribution to journalArticle

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AU - Li, Wen Qing

AU - Wang, Zhigang

AU - Hao, Sijie

AU - Sun, Liping

AU - Nisic, Merisa

AU - Cheng, Gong

AU - Zhu, Chuandong

AU - Wan, Yuan

AU - Ha, Laura

AU - Zheng, Si Yang

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