Mitochondria-based aircraft carrier enhances in vivo imaging of carbon quantum dots and delivery of anticancer drug

Wen Qing Li, Zhigang Wang, Sijie Hao, Liping Sun, Merisa Nisic, Gong Cheng, Chuandong Zhu, Yuan Wan, Laura Ha, Si Yang Zheng

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The application of engineered bacteria-based drug delivery vehicles to treat cancer has been practiced for more than a century. Mitochondria, evolutionarily originated from bacteria, are ubiquitous, semi-autonomous cellular organelles. In this study, we present the first exploration of using mitochondria as a delivery system of carbon quantum dots (CQDs) for in vivo imaging and administration of the anticancer drug doxorubicin (DOX). The results show that mitochondria as carriers are compatible with CQD loading and preserve the optical properties of CQDs. Moreover, the mitochondria delivery system can improve the CQD bio-distribution in organs and prolong the retention time of CQDs after intravenous injection. Furthermore, mitochondria loaded with doxorubicin hydrochloride (Mito-DOX) show an enhanced therapeutic effect compared to free DOX. The mitochondria-based "aircraft" system may be a promising novel therapeutic platform with high potential for biological imaging and drug delivery to fight cancer and other diseases.

Original languageEnglish (US)
Pages (from-to)3744-3752
Number of pages9
JournalNanoscale
Volume10
Issue number8
DOIs
StatePublished - Feb 28 2018

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All Science Journal Classification (ASJC) codes

  • Materials Science(all)

Cite this

Li, W. Q., Wang, Z., Hao, S., Sun, L., Nisic, M., Cheng, G., Zhu, C., Wan, Y., Ha, L., & Zheng, S. Y. (2018). Mitochondria-based aircraft carrier enhances in vivo imaging of carbon quantum dots and delivery of anticancer drug. Nanoscale, 10(8), 3744-3752. https://doi.org/10.1039/c7nr08816g